Effects of Rosa roxburghii & edible fungus fermentation broth on immune response and gut microbiota in immunosuppressed mice

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外文摘要：With the rise of probiotics fermentation in food industry,fermented foods have attracted worldwide attention.In this study,protective effects of Rosa roxburghii & edible fungus fermentation broth(REFB)on immune function and gut health in Cyclophosphamide induced immunosuppressed mice were investigated.Results showed that REFB could improve the immune organ index,and promote the proliferation and differentiation of splenic T lymphocytes.In addition,it attenuated intestinal mucosal damage and improved intestinal cellular immunity.REFB administration also up-regulated the expression of IL-4,INF-γ,TNF-α,T-bet and GATA-3 mRNA in small intestine.Furthermore,administration of REFB modulated gut microbiota composition and increased the relative abundance of beneficial genus,such as Bacteroides.It also increased the production of fecal short-chain fatty acids.These indicate that REFB has the potential to improve immunity,alleviate intestinal injury and regulate gut microbiota in immunosuppressed mice.

外文关键词：

Fermented foodsImmunosuppressed miceImmune responseGut microbiotaShort-chain fatty acids

作者：

Dechang Xu、Jielun Hu、Yadong Zhong、Yanli Zhang、Wenting Liu、Shaoping Nie、Mingyong Xie

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作者单位：

State Key Laboratory of Food Science and Technology,China-Canada Joint Laboratory of Food Science and Technology(Nanchang),Key Laboratory of Bioactive Polysaccharides of Jiangxi Province,Nanchang University,Nanchang 330047,China

基金：

国家自然科学基金重点项目Jiangxi High Level Talent Cultivation ProjectProject of State Key Laboratory of Food Science and TechnologyCentral Government Guide Local Special Fund Project for Scientific and Technological Development of Jiangxi Province

项目编号：

3213008220204BCJ24006SKLF-ZZA-20191120212ZDD02008

出版年：

2024

DOI：

10.26599/FSHW.2022.9250013

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(1)

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