首页|Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp(Penaeus vannamei)proteins in BALB/c mice
Insights into sensitizing and eliciting capacity of gastric and gastrointestinal digestion products of shrimp(Penaeus vannamei)proteins in BALB/c mice
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Shrimp(Penaeus vannamei)proteins have been shown an allergenic potential;however,little information is available on the sensitizing and eliciting capacity of shrimp protein digestion products.In this study,a BALB/c mice model was used to explore the allergenicity of shrimp protein sample(SPS)and their gastric and gastrointestinal digestion products(GDS/GIDS).As compared with the SPS groups,the GDS/GIDS groups caused lower specific immunoglobulins(IgE/IgG1)levels(P＜0.05),but higher than the control groups,indicating that the digestion products sensitized the mice.Meanwhile,spleen index,mouse mast cell protease-1(mMCP-1)concentration and proportion of degranulated mast cells were significantly reduced in the GDS/GIDS groups(P＜0.05);simultaneously,allergic symptoms,vascular permeability and histopathological changes of tissues were alleviated.Nevertheless,the allergenicity of digestion products cannot be eliminated and still cause systemic allergic reactions in mice.The study showed that the digestion products of shrimp still had high sensitizing and eliciting capacity.
Penaeus vannameiAllergenicityDigestionBALB/c mice model
Yao Liu、Songyi Lin、Kexin Liu、Shan Wang、Wang Li、Na Sun
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National Engineering Research Center of Seafood,School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,China
Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China
国家自然科学基金Dalian Sci-Tech Talent Innovation Support Program
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