Diet and physical activity influence the composition of gut microbiota,benefit on Alzheimer's disease

Jinyue Zhou ¹Min Tang ²Wanyi Li ²Rui Fang ¹Chunlan Tang ³Qinwen Wang¹

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作者信息

1. School of Public Health,Health Science Center,Ningbo University,Ningbo 315211,China
2. Department of Neurology,Ningbo Rehabilitation Hospital,Ningbo 3151000,China
3. School of Public Health,Health Science Center,Ningbo University,Ningbo 315211,China;Department of Neurology,Ningbo Rehabilitation Hospital,Ningbo 3151000,China;Ningbo Institute of Life and Health Industry,University of Chinese Academy of Sciences,Ningbo 315100,China
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Abstract

Alzheimer's disease is a neurodegenerative disease with complex etiology.Gut microbiota influences the gut-brain axis,which may affect pathways related to the pathogenesis of Alzheimer's disease.Additionally,diet and physical activity are likely to affect the pathology of Alzheimer's disease as well as the gut microbiota.This demonstrates that it may be possible to prevent or halt the progression of Alzheimer's disease by regulating the gut microbiota using diet and physical activity strategies.Therefore,the present study reviews the association between these two interventions and gut microbiota in the human body.It also summarizes how these two interventions benefit Alzheimer's disease.Furthermore,the primary limitations of these two interventions are discussed and promising strategies are proposed,which may be beneficial to further study and develop the intervening measure for the progression of Alzheimer's disease.

Key words

Alzheimer's disease/Gut microbiota/Brain-gut axis/Diet/Physical activity

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基金项目

国家自然科学基金(32171035)

major fund project of Ningbo Science and Technology Bureau(2019B10034)

Openedend Fund of Key Laboratory(KFJJ-202101)

Openedend Fund of Key Laboratory(ZPKLP202202)

Public Project of Ningbo(202002N3167)

Project of Yinzhou(2022AS025)

Ningbo Rehabilitation Hospital(2022KY02)

K.C.Wong Magna Fund in Ningbo University()

出版年

2024

食品科学与人类健康(英文)

CSTPCD

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参考文献量179

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