首页|Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice

Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice

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Sugarcane leaves-derived polyphenols(SLP)have been demonstrated to have diverse health-promoting benefits,but the mechanism of action has not been fully elucidated.This study aimed to investigate the anti-metabolic disease effects of SLP and the underlying mechanisms in mice.In the current study,we prepared the SLP mainly consisting of three flavonoid glycosides,three phenol derivatives,and two lignans including one new compound,and further demonstrated that SLP reduced body weight gain and fat accumulation,improved glucose and lipid metabolism disorders,ameliorated hepatic steatosis,and regulated short-chain fatty acids(SCFAs)production and secondary bile acids metabolism in ob/ob mice.Notably,SLP largely altered the gut microbiota composition,especially enriching the commensal bacteria Akkermansia muciniphila and Bacteroides acidifaciens.Oral gavage with the above two strains ameliorated metabolic syndrome(MetS),regulated secondary bile acid metabolism,and increased the production of SCFAs in high-fat diet(HFD)-induced obese mice.These results demonstrated that SLP could be used as a prebiotic to attenuate MetS via regulating gut microbiota composition and further activating the secondary bile acids-mediated gut-adipose axis.

Sugarcane leaves-derived polyphenolsMetabolic syndromeBacteroides acidifaciensAkkermansia muciniphilaSecondary bile acids metabolism

Li Sun、Tao Wang、Baosong Chen、Cui Guo、Shanshan Qiao、Jinghan Lin、Huan Liao、Huanqin Dai、Bin Wang、Jingzu Sun、Hongwei Liu

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State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

Savaid Medicine School,University of Chinese Academy of Sciences,Beijing 100101,China

Guangxi Academy of Sciences,Nanning 530007,China

国家重点研发计划Science and Technology Service Network Program of the Chinese Academy of SciencesStrategic Priority Research Program(Class B)of Chinese Academy of Sciences

2019YFA0905600KFJ-STS-QYZD-201-5-3XDB38020300

2024

10.26599/FSHW.2022.9250048

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(2)
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