Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

Qian Chen ¹Chunxia Mei ¹Min Guo ²Botao Wang ³Haiqin Chen ²Jianxin Zhao ²Gang Wang ²Wei Chen⁴

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作者信息

1. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China
2. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China;(Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China
3. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;Bloomage Biotechnology Co.,Ltd.,Jinan 250000,China
4. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China
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Abstract

Lipid metabolism disorders commonly occur during menopause.Estrogen deficiency has been shown to lead to excessive energy intake and abnormal lipid metabolism in ovariectomized rats,resulting in obesity.Probiotics exhibit anti-obesity properties,and their underlying mechanism has been widely reported.In this study,we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 in suppressing appetite,controlling body weight,correcting obesity-induced abnormalities,enhancing liver lipid metabolism,and protecting liver function in estrogen-deficient rats.The mechanisms associated with the anti-obesity and anti-dyslipidemia effects of CCFM1180 on estrogen-deficient rats were clarified.The results showed that CCFM1180 dramatically reduced food intake by activating the expression of estrogen receptor alpha(ERa)and increasing the level of leptin in abdominal adipose tissue.These changes,combined with the increased butyrate concentration and recovered bile acid structure,helped enhance lipid metabolism.Additionally,CCFM1180 treatment was found to be safer than exogenous estrogen supplementation.Thus,L.plantarum CCFM1180 could be considered a new therapeutic strategy for preventing and alleviating menopausal lipid abnormalities.

Key words

Bile acid/Gut microbiota/Menopause/Ovariectomy/Short chain fatty acid

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基金项目

国家自然科学基金(31972052)

国家自然科学基金(32021005)

国家自然科学基金(31820103010)

中央高校基本科研业务费专项(JUSRP22006)

中央高校基本科研业务费专项(JUSRP51501)

Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province()

出版年

2024

食品科学与人类健康(英文)

CSTPCDCSCD

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参考文献量60

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