首页|The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study
The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study
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Intestinal microbiota imbalance may worsen the progression of ulcerative colitis(UC).Lacticaseibacillus rhamnosus LS8(LR)has the potential ability to regulate microbiota through producing a novel antibacterial substance,cyclic opine:cycloalanopine.This study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation(FMT)experiment.The results showed that both LR and FMT attenuated UC as evidenced by 1)alleviating disease activity index and colonic pathology;2)up-regulating MUCs and tight junction proteins;3)increasing oxidative mediators and decreasing antioxidant mediators;4)down-regulating proinflammatory cytokines and chemokines.These results were mainly attributable to the microbiota-regulating effect of LR,including increasing beneficial bacteria(like Akkermansia)and its related SCFAs,while decreasing harmful bacteria(like Proteobacteria)and its related LPS,thereby suppressing the hyperactivation of TLR4/NF-κB pathway.Consequently,LR can alleviate UC and is a potential dietary supplement to attenuate UC.
Gut barrierGut microbiotaFecal microbiota transplantationLacticaseibacillus rhamnosusOxidative stressUlcerative colitis
Tao Wang、Shuang Wang、Shuchen Dong、Ruiling Wang、Shuxuan Wang、Jie Yang、Xin Wang、Xin Lü
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College of Food Science and Engineering,Northwest Agriculture and Forestry University,Yangling 712100,China
Faculty of Food Science and Engineering,Kunming University of Science and Technology,Kunming 650500,China
School of Life Science and Technology,Xinjiang University,Urumqi 830046,China
国家自然科学基金国家自然科学基金Keypoint Research and Invention Program of Shannxi Province
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