The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study

Tao Wang ¹Shuang Wang ²Shuchen Dong ²Ruiling Wang ²Shuxuan Wang ²Jie Yang ³Xin Wang ²Xin Lü²

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作者信息

1. College of Food Science and Engineering,Northwest Agriculture and Forestry University,Yangling 712100,China;Faculty of Food Science and Engineering,Kunming University of Science and Technology,Kunming 650500,China
2. College of Food Science and Engineering,Northwest Agriculture and Forestry University,Yangling 712100,China
3. School of Life Science and Technology,Xinjiang University,Urumqi 830046,China
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Abstract

Intestinal microbiota imbalance may worsen the progression of ulcerative colitis(UC).Lacticaseibacillus rhamnosus LS8(LR)has the potential ability to regulate microbiota through producing a novel antibacterial substance,cyclic opine:cycloalanopine.This study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation(FMT)experiment.The results showed that both LR and FMT attenuated UC as evidenced by 1)alleviating disease activity index and colonic pathology;2)up-regulating MUCs and tight junction proteins;3)increasing oxidative mediators and decreasing antioxidant mediators;4)down-regulating proinflammatory cytokines and chemokines.These results were mainly attributable to the microbiota-regulating effect of LR,including increasing beneficial bacteria(like Akkermansia)and its related SCFAs,while decreasing harmful bacteria(like Proteobacteria)and its related LPS,thereby suppressing the hyperactivation of TLR4/NF-κB pathway.Consequently,LR can alleviate UC and is a potential dietary supplement to attenuate UC.

Key words

Gut barrier/Gut microbiota/Fecal microbiota transplantation/Lacticaseibacillus rhamnosus/Oxidative stress/Ulcerative colitis

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基金项目

国家自然科学基金(32001652)

国家自然科学基金(2452018062)

Keypoint Research and Invention Program of Shannxi Province(2021ZDLNY05-06)

出版年

2024

食品科学与人类健康(英文)

CSTPCDCSCD

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参考文献量41

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