首页|Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye
Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye
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Type 2 diabetes mellitus(T2DM)is a complex metabolic disease threatening human health.We investigated the effects of Tegillarca granosa polysaccharide(TGP)and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin.TGP(5.1 x 103 Da)was composed of mannose,glucosamine,rhamnose,glucuronic acid,galactosamine,glucose,galactose,xylose,and fucose.It could significantly alleviate weight loss,reduce fasting blood glucose levels,reverse dyslipidemia,reduce liver damage from oxidative stress,and improve insulin sensitivity.RT-PCR and Western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance.TGP increased the abundance of Allobaculum,Akkermansia,and Bifidobacterium,restored the microbiota abundance in the intestinal tracts of mice with T2DM,and promoted short-chain fatty acid production.This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.
College of Food Science and Technology,Zhejiang University of Technology,Hangzhou 310014,China
Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province,Hangzhou 310014,China
National R&D Branch Center for Pelagic Aquatic Products Processing(Hangzhou),Hangzhou 310014,China
Institute of Sericultural and Tea,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China
College of Food and Pharmacy,Zhejiang Ocean University,Zhoushan 316000,China
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国家重点研发计划Zhejiang Province Public Welfare Technology Application Research ProjectZhejiang Provincial Key Research and Development Project of ChinaZhejiang Provincial Key Research and Development Project of China
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