首页|The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier
The efficiency and safety evaluation of hemoglobin hydrolysate as a non-heme iron fortifier
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Hemoglobin hydrolysate is derived from the enzymatic degradation of hemoglobin.This work aimed to evaluate whether hemoglobin hydrolysate promotes the absorption of non-heme iron and the safety of absorbed iron in mice by analyzing the iron binding content,iron circulation,and liver homeostasis.We found that hemoglobin hydrolysate promoted the absorption of non-heme iron with high efficiency in duodenum by spontaneously binding non-heme iron during digestion,and increased hepatic iron content by up-regulating divalent metal transporter 1,zinc transporter 14,but hepatic iron content only increased at 3 weeks.Duodenal iron entered the blood through ferroportin without restriction at 3 weeks,and excessive iron entered the liver and then affected the hepatocyte membranes permeability and lipid synthesis through oxidative stress.With the prolongation of dietary intervention,the up-regulated hepcidin acted on the ferroportin to restrict excess iron from entering the blood,and then the hepatic homeostasis recovered.In addition,hemoglobin hydrolysate enhanced the hepatic antioxidant capacity.Taken together,hemoglobin hydrolysate has a strong ability to promote the absorption of non-heme iron in vivo,and the absorbed iron is relatively safe due to the regulation of hepcidin.
Dejiang Xue、Shuai Jiang、Miao Zhang、Kai Shan、René Lametsch、Chunbao Li
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Key Laboratory of Meat Processing and Quality Control,Ministry of Education,Key Laboratory of Meat Processing,Ministry of Agriculture and Rural Affairs,Jiangsu Collaborative Innovation Center of Meat Production,Processing and Quality Control,College of Food Science and Technology,Nanjing Agricultural University,Nanjing 210095,China
Department of Food Science,University of Copenhagen,Frederiksberg C DK-1958,Denmark
国家自然科学基金Jiangsu Province Department of Education(Innovation Group of Meat Nutrition and Biotechnology)
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