Epicatechin attenuates lead(Pb)-induced cognitive impairment in mice:regulation on Nrf2 signaling pathway,and interference on the interaction between Pb with albumin

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外文摘要：Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in mice.Eight-week-old male Kunming mice were treated with PbCl2(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 weeks.Morris water maze test showed that EC could improve memory dysfunction induced by Pb.EC antagonized Ca2+ overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in mice.In vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb2+in presence or absence of EC.EC was proved to chelate Pb2+and reduced the interaction between BSA and Pb2+.In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

外文关键词：

LeadEpicatechinBovine serum albuminInteractionOxidative stress

作者：

Dai Cheng、Qianqian Yu、Kexin Zhu、Dingdong Bu、Zijian Wu

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作者单位：

State Key Laboratory of Food Nutrition and Safety,Tianjin University of Science & Technology,Tianjin 300457,China

School of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China

基金：

国家重点研发计划Graduate Scientific Research Innovation Project of TianjiProject of Tianjin Science and Technology ProgramProject of Tianjin Science and Technology Program

项目编号：

2022YFF11028002022SKY10922JCYBJC0036021ZYJDJC00060

出版年：

2024

DOI：

10.26599/FSHW.2022.9250092

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(2)

参考文献量50