首页|Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

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The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are limited.Herein,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral ovariectomy.After 3 months of FM(containing vitamin D,and casein phosphopeptides,1 000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical testing.The results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid biosynthesis.Furthermore,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and microarchitecture.Mechanistically,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen type I N-propeptide,and decreased expression of the bone resorption marker C-telopeptide and tartrate-resistant acid phosphatase 5b.Overall,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.

Dairy productsCalciumVitamin DBone turnover markersGut microbiotaPostmenopausal osteoporosis

Qishan Wang、Bin Liu、Xianping Li、Junying Zhao、Zongshen Zhang、Weicang Qiao、Xinyue Wei、Lijun Chen

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School of Bioengineering,Dalian Polytechnic University,Dalian 116034,China

National Engineering Research Center of Dairy Health for Maternal and Child,Beijing Sanyuan Foods Co.Ltd.,Beijing 100163,China

Beijing Engineering Research Center of Dairy,Beijing Sanyuan Foods Co.Ltd.,Beijing 100163,China

国家自然科学基金Daxing District Major Scientific and Technological Achievements Transformation ProjectBeijing Innovation Team Project of Livestock Industry Technology SystemBeijing Science and Technology Special Project

320721912020006Z201100002620005

2024

10.26599/FSHW.2022.9250105

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(3)
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