Elaidic acid-induced intestinal barrier damage led to gut-liver axis derangement and triggered NLRP3 inflammasome in the liver of SD rats

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外文摘要：Previous studies have shown that trans fatty acids(TFA)are associated with several chronic diseases,the gut microbiota is directly influenced by dietary components and linked to chronic diseases.Our research investigated the effects of elaidic acid(EA),a typical TFA,on the gut microbiota to understand the underlying mechanisms of TFA-related chronic diseases.16S rDNA gene sequencing on faecal samples from Sprague-Dawley rats were performed to explore the composition change of the gut microbiota by EA gavage for 4 weeks.The results showed that the intake of EA increased the abundance of well-documented harmful bacteria,such as Proteobacteria,Anaerotruncus,Oscillibacter and Desulfovibrionaceae.Plus,EA induced translocation of lipopolysaccharides(LPS)and the above pathogenic bacteria,disrupted the intestinal barrier,led to gut-liver axis derangement and TLR4 pathway activation in the liver.Overall,EA induced intestinal barrier damage and regulated TLR4-MyD88-NF-κB/MAPK pathways in the liver of SD rats,leading to the activation of NLRP3 inflammasome and inflammatory liver damage.

外文关键词：

Elaidic acid(EA)Gut microbiotaIntestinal barrierGut-liver axisTLR4-MyD88-NF-κB/MAPK pathwaysNLRP3 inflammasome

作者：

Hui Liu、Xuenan Li、Lu Li、Yucai Li、Haiyang Yan、Yong Pang、Wenliang Li、Yuan Yuan

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作者单位：

College of Food Science and Engineering,Jilin University,Changchun 130062,China

School of Public Health,Jining Medical University,Jining 272067,China

基金：

fund from the National Natural Science Foundation of China山东省自然科学基金Shandong Traditional Chinese Medicine Technology Project

项目编号：

32172322ZR2023QC291Q-2023130

出版年：

2024

DOI：

10.26599/FSHW.2022.9250107

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(3)

参考文献量55