首页|Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice

Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice

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F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in animals.Betulinic acid(BA)is a natural pentacyclic lupane-structure triterpenoid that has diverse pharmacological activities.In this study,the antioxidative and anti-inflammatory effects of BA and its underlying mechanism are explored in F-2 toxin-triggered mouse ovarian damage.We found that BA alleviated the F-2 toxin-induced ovarian impairment by stimulating follicle growth,reducing inflammatory cell infiltration,repairing damaged mitochondria and endoplasmic reticulum.Simultaneously,BA not only reversed F-2 toxin-induced reduction of follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in the serum,but also restrained the protein expression of the estrogen receptors α(ERα)and ERβ.Moreover,BA restored the balance of F-2 toxin-induced ovarian redox system disorders.Subsequently,we found that 0.25 mg/kg BA played an anti-inflammatory role in the F-2 toxin-induced ovarian impairment by decreasing interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)mRNA expression,as well as inhibiting p38 protein expression.These data demonstrated that BA exerts its protective effect on F-2 toxin-induced ovarian oxidative impairment and inflammation by inhibiting p38 expression,which implies a natural product-based medicine to ameliorate F-2 toxin-caused female reproductive toxicity and provides a detoxifying method for food contaminated by mycotoxin.

Betulinic acidF-2 toxinOvarian damagep38 MAPK signaling pathway

Li Kong、Xinyu Gao、Lijuan Zhu、Xing Lin、You Huang、Chunlin Huang、Wenjiang Yang、Yazhi Chen、Haoqiang Zhao、Jing Wu、Zhihang Yuan、Jin'e Yi

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Hunan Engineering Research Center of Livestock and Poultry Health Care,College of Veterinary Medicine,Hunan Agricultural University,Changsha 410128,China

国家自然科学基金Special Funds for Construction of Innovative Provinces in Hunan Province,China湖南省自然科学基金Innovation Foundation for Postgraduate of Hunan ProvinceInnovation Foundation for Postgraduate of Hunan Agricultural University,China

322730842020NK20322020JJ4368CX202206702022XC010

2024

10.26599/FSHW.2022.9250108

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(3)
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