首页|Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Peanut allergy is majorly related to severe food induced allergic reactions.Several food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90％of food allergies.Here,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and soybean.Additionally,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and dry-roasted.Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic response.The results obtained from this study will direct future experimental and clinical studies to understand the role of dietary lipids and PPAR-isoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

Allergy informaticsKnowledge-graphData analysisFood allergyPeroxisome proliferator-activated receptorsFatty acids

Emmanuel Kemmler、Julian Braun、Florent Fauchère、Sabine D?lle-Bierke、Kirsten Beyer、Robert Preissner、Margitta Worm、Priyanka Banerjee

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Institute for Physiology,Charité-University Medicine Berlin,Berlin 10115,Germany

Member of the KFO339,FOOD@,Berlin 10115,Germany

Si-M/"Der Simulierte Mensch"a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin,Berlin 10115,Germany

Charité-Universitätsmedizin Berlin,corporate member of Freie Universität Berlin,Humboldt-Universität zu Berlin,and Berlin Institute of Health,Berlin 10115,Germany

Division of Allergy and Immunology,Department of Dermatology,Venerology and Allergy,Charité-Universitätsmedizin Berlin,corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin,Berlin 10115,Germany

Pediatrics,Campus Virchow,Charité-University Medicine Berlin,Berlin 10115,Germany

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2024

10.26599/FSHW.2022.9250111

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(3)
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