Veratrilla baillonii Franch alleviate the symptoms of diabetes in type 2 diabetic rats induced by high-fat diet and streptozotocin

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外文摘要：Our previous research studies have shown that Veratrilla baillonii Franch,a food supplement used by ethnic minorities in Southwest China,has multiple pharmacological activities,such as detoxification,anti-inflammatory,antioxidant,and anti-insulin resistance.However,the detailed signal pathways for its salutary effect on damages in multiple organs due to type 2 diabetes mellitus(T2DM)remains unclear.The current study is to evaluate the therapeutic effects of V.baillonii on T2DM rats and to explore the underlying mechanisms.The T2DM rat model was successfully established by a high-sugar and high-fat diet(HFD)combination with intraperitoneal injection of a small dose of streptozotocin(STZ,35 mg/kg).Biochemical analysis and histopatholgical examinations were conducted to evaluate the anti-diabetic potential of water extracts of V baillonii(WVBF).The results showed that the WVBF treatment can improve hyperglycemia and insulin resistance,ameliorate the liver,kidney and pancreas injuries via decreasing inflammatory cytokines such as IL-6 and TNF-α,and oxidative damages.Further investigation suggested that WVBF modulates the signal transductions of the IRS1/PI3K/AKT/GLUT4 and AMPK pathways.These findings demonstrate potentials of WVBF in the treatment of T2DM and possible mechanisms for its hepatoprotective activities.

外文关键词：

Veratrilla baillonii FranchType 2 diabetes mellitusLiver injurySkeletal muscleGLUT4

作者：

Chunlan Yan、Zhihao Zhang、Liqun Ma、Xinyi Xu、Muhammad Azhar、Xianju Huang、Jianxun Shi、Jun Li

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作者单位：

College of Life Sciences,South-Central Minzu University,Wuhan 430074,China

College of Pharmaceutical Science,South-Central Minzu University,Wuhan 430074,China

Department of Biosciences,COMSATS University Islamabad,Sahiwal 57000,Pakistan

Zhejiang Pharmaceutical University,Ningbo 315100,China

Ethnopharmacology Level 3 Laboratory,National Administration of Traditional Chinese Medicine,South-Central Minzu University,Wuhan 430074,China

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基金：

国家自然科学基金Support Innovation and Development of Enterprise Technology Projects in Hubei Provincemodern transmission and innovation research team of Traditional Chinese Medicine,South Central Minzu University

项目编号：

818730902021BLB174

出版年：

2024

DOI：

10.26599/FSHW.2022.9250116

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(3)

参考文献量36