首页|Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children
Lactose-free milk powder can effectively relieve diarrhea symptoms in weaning SD rats and children
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Diarrhea has become the leading cause of illness and death among infants and young children in developing countries.Clinically,patients with diarrhea showed damaged intestinal epithelial villi,usually accompanied by lactase deficiency.In this study,we evaluated the therapeutic effects of lactose-free milk powder on rats and children with diarrhea.Antibiotic-associated diarrhea(AAD)model was established by gavage with antibiotic mixture in SD rats,followed by administration of milk powder containing lactose or not.The results showed that lactose-free milk powder ameliorated AAD-related diarrhea symptoms,and accelerated the recovery from diarrhea.And 16S sequencing results indicated lactose-free milk powder contributed to increase theα-and β-diversity of intestinal flora,and restore the intestinal microbiota disorder.In conclusion,our data demonstrate that lactose-free milk powder could alleviate diarrhea by restoring gut microbiota and intestinal barrier function.
Manman Liu、Shiwen Han、Boya Li、Cheng Chen、Lu Yao、Jung-il Kwon、Juan Jin、Huilian Che
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Beijing Advanced Innovation Center for Food Nutrition and Human Health,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China
Maeil Innovation Center,Maeil Dairies Co.,Ltd.,Seoul 03142,South Korea
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