Polysaccharides of Aspergillus cristatus attenuate obesity by regulating gut microbiota and gut microbiota-related metabolites

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外文摘要：Golden-flower fungus,the only dominant microorganism determining the Fu-brick tea quality through fermentation and the important microbe in Liupao tea,is considered a potential probiotic fungus based on its anti-obesity effect.However,the classification of golden-flower fungi is still controversial;the anti-obesity effect of golden-flower fungus polysaccharides remains unknown.In this study,we identify a golden-flower strain as Aspergillus cristatus based on morphological characteristics and multigene phylogeny analysis,which resolves the controversy of classification.Moreover,we find A.cristatus polysaccharides(ACPS)attenuate obesity in rats.ACPS modulate gut bacterial composition,in which Akkermansia,Akkermansia muciniphila,Bacteroides,Romboutsia,Blautia,and Desulfovibrio are considered the core microbes regulated by ACPS.ACPS increase fecal total short-chain fatty acid content and serum,hepatic,and fecal total bile acid content.Furthermore,ACPS-induced gut microbiota alteration plays a causal role in the protection from obesity,according to a fecal transplantation experiment.Thus,ACPS ameliorate obesity by regulating gut microbiota and gut microbiota-related metabolites.

外文关键词：

Golden-flower fungusAspergillus cristatusPolysaccharidesObesityGut microbiota

作者：

Mingzhi Zhu、Bohao Shang、Fang Zhou、Yong Yuan、Feiyan Yin、Jin Cao、Jianan Huang、Kunbo Wang、Xin Zeng、Maiquan Li、Zhonghua Liu

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作者单位：

College of Horticulture,Hunan Agricultural University,Changsha 410128,China

College of Life Sciences,Huaibei Normal University,Huaibei 235000,China

Hunan Tea Group Co.,Ltd.,Changsha 410128,China

School of Food Science and Technology,Hunan Agricultural University,Changsha 410128,China

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基金：

国家自然科学基金国家自然科学基金Major Project of Science and Technology of Guangxi Zhuang Autonomous Region湖南省重点研发计划Hunan"Three Top"Innovative Talents ProjectNatural Science Foundation of Hunan Province for Outstanding Young ScholarsTraining Program for Excellent Young Innovators of ChangshaScientific Research Fund of the Hunan Provincial Education Department

项目编号：

3200209532172217AA203020182020WK20172022RC11422022JJ20028kq210701520A241

出版年：

2024

DOI：

10.26599/FSHW.2022.9250128

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(3)

参考文献量62