首页|Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Limosilactobacillus mucosae on NAFLD were investigated in this study.Four-week-old male C57BL/6J mice were divided into 4 groups(n=8 per group,Control,Model,FZJTZ26M3,FGSYC17L3).L.mucosae FZJTZ26M3 reduced the mice's body weight,liver weight,and adipose tissue weight after 12 weeks of therapy.According to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after L.mucosae FZJTZ26M3 intervention.Liver pathology showed that L.mucosae FZJTZ26M3 was effective to ameliorate lipid deposition in NAFLD mice.Additionally,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that L.mucosae FZJTZ26M3 could alleviate NAFLD by regulating lipid metabolism.Furthermore,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after L.mucosae FZJTZ26M3 intervention.Generally,L.mucosae FZJTZ26M3 could be a candidate to prevent NAFLD.

Limosilactobacillus mucosaeNonalcoholic fatty liver disease(NAFLD)ProbioticLipid metabolismGut microbiota

Danting Dang、Bowen Li、Mengfan Ding、R.Paul Ross、Catherine Stanton、Jianxin Zhao、Bo Yang、Wei Chen

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State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China

School of Food Science and Technology,Jiangnan University,Wuxi 214122,China

International Joint Research Center for Probiotics & Gut Health,Jiangnan University,Wuxi 214122,China

APC Microbiome Ireland,University College Cork,Cork T12 YT20,Ireland

Teagasc Food Research Centre,Moorepark,Fermoy,Cork T12 YT20,Ireland

National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China

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国家自然科学基金国家自然科学基金高等学校学科创新引智计划(111计划)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province

3202100531820103010BP0719028

2024

10.26599/FSHW.2022.9250134

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(3)
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