首页|Voluntary wheel running ameliorated the deleterious effects of high-fat diet on glucose metabolism,gut microbiota and microbial-associated metabolites

Voluntary wheel running ameliorated the deleterious effects of high-fat diet on glucose metabolism,gut microbiota and microbial-associated metabolites

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Exercise training is critical for the early prevention and treatment of obesity and diabetes mellitus.However,the mechanism with gut microbiota and fecal metabolites underlying the effects of voluntary wheel running on high-fat diet induced abnormal glucose metabolism has not been fully elaborated.C57BL/6 male mice were randomly assigned to 4 groups according to diets(fed with normal chow diet or high-fat diet)and running paradigm(housed in static cage or with voluntary running wheel).An integrative 16S rDNA sequencing and metabolites profiling was synchronously performed to characterize the effects of voluntary wheel running on gut microbiota and metabolites.It showed that voluntary wheel running prevented the detrimental effects of high-fat feeding on glucose metabolism.16S rDNA sequencing showed remarkable changes in Rikenella and Marvinbryantia genera.Metabolic profiling indicated multiple altered metabolites,which were enriched in secondary bile acid biosynthesis signaling.In conclusion,our study indicated that voluntary wheel running significantly improved glucose metabolism and counteracted the deleterious effects of high-fat feeding on body weight and glucose intolerance.We further found that voluntary wheel running could integratively program gut microbiota composition and fecal metabolites changes,and may regulate muricholic acid metabolism and secondary bile acid biosynthesis in high-fat fed mice.

High-fat dietVoluntary wheel runningGut microbiotaMetabolomicsGlucose metabolism

Ling Zhang、Wenyu Zou、Yongyan Hu、Honghua Wu、Ying Gao、Junqing Zhang、Jia Zheng

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Department of Endocrinology,Peking University First Hospital,Beijing 100034,China

Laboratory Animal Facility,Peking University First Hospital,Beijing 100034,China

国家自然科学基金国家自然科学基金北京市科技新星计划北京市科技新星计划北京市自然科学基金北京市自然科学基金Fundamental Research Funds for the Central Universities,Peking University Clinical Scientist Training ProgramChina Endocrine and Metabolism Young Scientific Talent Research ProjectPeking University Medicine Seed Fund for Interdisciplinary Research中央高校基本科研业务费专项China Diabetes Young Scientific Talent Research ProjectBethune-Merck Diabetes Research Fund of Bethune Charitable Foundation

8180070381970701Z2011000068201172022048418171842527214258BMU2023PYJH0222022-N-02-01BMU2021MX013G2018030

2024

10.26599/FSHW.2022.9250142

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(3)
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