首页|Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

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We evaluated the effect of isoquercetin(quercetin-O-3-glucoside-quercetin,IQ)as a functional component of Abeliophyllum disistichum Nakai ethanol extract(ADLE)on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia(BPH).Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and HPLC.IQ was orally administered(1 or 10 mg/kg)to a testosterone propionate-induced BPH rat model,and its effects on the prostate weight were evaluated.The effect of IQ on androgen receptor(AR)signaling was analyzed in LNCaP cells.Whether IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also examined.The metabolites in ADLE were identified and quantified,which confirmed that ADLE contained abundant IQ(20.88 mg/g).IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model,and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent manner.IQ also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 cells.In BPH-1 cells,IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing apoptosis.Thus,IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

IsoquercetinBenign prostatic hyperplasiaAndrogen receptor signalingPI3K/Akt/mtor pathway

Young-Jin Choi、Meiqi Fan、Nishala Erandi Wedamulla、Yujiao Tang、Eun-Kyung Kim

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Department of Food Science and Nutrition,Dong-A University Busan 49315 Republic of Korea

Center for Silver-targeted Biomaterials,Brain Busan 21 Plus program,Dong-A University,Busan 49315,Republic of Korea

Department of Health Sciences,the Graduate School of Dong-A University,Busan 49315,Republic of Korea

Division of Food Bioscience,College of Biomedical and Health Sciences,Konkuk University,Chungju 27478,Republic of Korea

Department of Export Agriculture,Faculty of Animal Science and Export Agriculture,Uva Wellassa University,Badulla 90000,Sri Lanka

School of Bio-Science and Food Engineering,Changchun University of Science and Technology,Changchun 130600,China

Nutritional Education Major,Graduate School of Education,Dong-A University,Busan 49315,Republic of Korea

Nutrinomics Lab.Co.,Ltd.,Busan 49315,Republic of Korea

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Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Sci

NRF-2020R1A2C1014798

2024

10.26599/FSHW.2022.9250216

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(3)
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