Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

Jiang Cao ¹Leilei Yu ¹Jianxin Zhao ¹Hao Zhang ²Wei Chen ³Yuzheng Xue ⁴Qixiao Zhai¹

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作者信息

1. State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China
2. State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China;Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch,Wuxi 214122,China
3. State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China
4. Department of Gastroenterology,Affiliated Hospital of Jiangnan University,Wuxi 214122,China
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Abstract

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different strains.Thus,6 B.coagulans strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of B.coagulans strains are strain-specific.The results of this study showed that the ingestion of B.coagulans GBI-30,6086,and B.coagulans CCFM1041 significantly alleviated IBS symptoms in mice.In contrast,other B.coagulans strains showed no or limited alleviating effects on IBS symptoms.According to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary metabolites.Screening strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional B.coagulans strains.Our results also suggest that administration of B.coagulans could significantly regulate microbiota dysbiosis in animal models.Moreover,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

Key words

Baciillus coagulans/Irritable bowel syndrome/Resistance to bile salts/Comparative genomic analysis/Gut microbiota

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基金项目

江苏省自然科学基金(BK20200084)

国家自然科学基金(31871773)

国家自然科学基金(31820103010)

Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province()

Key Talents Project of"Strengthening Health through Science and Education"of Wuxi Health and Family Planning Commission(ZDRC039)

Top Talents Project of"Six-one Project"for High-level Health Talents in Jiangsu Province(LGY2018016)

出版年

2024

食品科学与人类健康(英文)

CSTPCD

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参考文献量3

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