首页|Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

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The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different strains.Thus,6 B.coagulans strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of B.coagulans strains are strain-specific.The results of this study showed that the ingestion of B.coagulans GBI-30,6086,and B.coagulans CCFM1041 significantly alleviated IBS symptoms in mice.In contrast,other B.coagulans strains showed no or limited alleviating effects on IBS symptoms.According to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary metabolites.Screening strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional B.coagulans strains.Our results also suggest that administration of B.coagulans could significantly regulate microbiota dysbiosis in animal models.Moreover,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

Baciillus coagulansIrritable bowel syndromeResistance to bile saltsComparative genomic analysisGut microbiota

Jiang Cao、Leilei Yu、Jianxin Zhao、Hao Zhang、Wei Chen、Yuzheng Xue、Qixiao Zhai

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State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China

School of Food Science and Technology,Jiangnan University,Wuxi 214122,China

National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China

Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch,Wuxi 214122,China

Department of Gastroenterology,Affiliated Hospital of Jiangnan University,Wuxi 214122,China

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江苏省自然科学基金国家自然科学基金国家自然科学基金Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu ProvinceKey Talents Project of"Strengthening Health through Science and Education"of Wuxi Health and Family Planning CommissionTop Talents Project of"Six-one Project"for High-level Health Talents in Jiangsu Province

BK202000843187177331820103010ZDRC039LGY2018016

2024

10.26599/FSHW.2022.9250153

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(4)
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