首页|Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders-a Mendelian randomization study
Causal relationship between circulating vitamin C and 25-hydroxyvitamin D concentrations and common mental disorders-a Mendelian randomization study
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Mental disorders seriously affect people's health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental disorders.The data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the FinnGen consortium for fourteen mental disorders.Based on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95％CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P＞0.05).In the reverse MR analysis,individuals with Alzheimer's disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders.In addition,there was no causal association between circulating VC and 25(OH)D(P＞0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,and Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009,China
Department of Integrated Service and Management,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China
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