Abstract
Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived mice.CCFM1025 improved the body weight and food and water intake of the mice.It also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related behaviours.CCFM1025 significantly altered the gut microbial composition and genome function.Key microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid and y-aminobutyric acid in the gut and purine metabolites in the serum.Those metabolites may participate in gut-brain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1.Collectively,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites.These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.
基金项目
江苏省自然科学基金(BK20210456)
国家自然科学基金(32201988)
国家自然科学基金(31972052)
国家自然科学基金(32021005)
国家自然科学基金(31820103010)
中央高校基本科研业务费专项(JUSRP22006)
中央高校基本科研业务费专项(JUSRP51501)
China National Postdoctoral Program for Innovative Talents(BX2021114)
中国博士后科学基金(2021M691290)
Postdoctoral Science Foundation of Jiangsu Province(2021K127B)
Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province()
维普
万方数据