首页|Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome

Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome

扫码查看
原文链接
  • 万方数据
  • 维普
Metabolic syndrome(MetS)is a chronic disease associated with the disturbance of gut microbiota homeostasis.Metabolites derived from gut microbes play essential roles in MetS prevention and therapy.Here,we focused on the inhibitory effect of the extract of millet bran protein(EMBP)on a high-fat diet(HFD)-induced MetS,aiming to identify gut microbiota and their metabolites that involve in the anti-MetS activity of EMBP.The obesity,chronic inflammation,insulin resistance in MetS mouse models were abolished after EMBP treatment.The protective mechanism of EMBP against HFD-induced MetS may depend on improved gut barrier function.Using microbiome analysis,we found that EMBP supplementation improved gut microbiome dysbiosis in MetS mice,specifically upregulating Bacteroides acidifaciens.The fecal microbiota transplantation(FMT)also demonstrated this phenomenon.In addition,metabolomic analysis showed that EMBP mediates metabolic profiling reprogramming in MetS mice.Notably,a microbiota-derived metabolite,gamma-aminobutyric acid(GABA),is enriched by EMBP.In addition,exogenous GABA treatment produced a similar protective effect to EMBP by improving NRF2-dependent gut barrier function to protect HFD-induced MetS.The results suggest that EMBP suppress host MetS by remodeling of gut microbiota as an effective candidate for next-generation medicine food dual purpose dietary supplement to intervene in MetS.

Metabolic syndromeGut microbiotaExtract of millet bran proteinGamma-aminobutyric acidGut barrier function

Shuhua Shan、Ruopeng Yin、Jiangying Shi、Lizhen Zhang、Jiaqi Zhou、Qinqin Qiao、Xiushan Dong、Wenjing Zhao、Zhuoyu Li

展开 >

Institute of Biotechnology,Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education,Shanxi University,Taiyuan 030006,China

School of Life Science,Shanxi University,Taiyuan 030006,China

Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Third Hospital of Shanxi Medical University,Taiyuan 030032,China

Department of Biology,Biological Science and Technology College,Taiyuan Normal University,Jinzhong 030619,China

展开 >

国家自然科学基金国家自然科学基金国家重点研发计划Shanxi Province Science FoundationShanxi Key Laboratory for Research and Development of Regional PlantsShanxi Province"136"Revitalization Medical Project Construction Funds

32270420320722202020YFD1001405202103021224011

2024

10.26599/FSHW.2022.9250165

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(4)
  • 58