首页|Association of plasma vitamin A level with type 2 diabetes mellitus:a community aging population-based cross-sectional study

Association of plasma vitamin A level with type 2 diabetes mellitus:a community aging population-based cross-sectional study

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Recent studies indicated that vitamin A(VA)might be involved in the pathology of type 2 diabetes mellitus(T2DM).This cross-sectional study was conducted to explore the association between circulating VA level and T2DM.A total of 1 818 subjects aged 50 years old and above were recruited from the community.Binomial logistic regression and restricted cubic spline(RCS)were applied to analyze the association of plasma VA level with the risk of T2DM.Serum VA and lipid-adjusted VA levels of T2DM patients were significantly higher than that of non-T2DM subjects(P＜0.05).The ratios of plasma VA/total cholesterol(TC),VA/high-density lipoprotein cholesterol(HDL-c)and VA/low-density lipoprotein cholesterol(LDL-c)were positively associated with the risk of T2DM in the aging population(P＜0.05).Compared with the Q1 level,subjects with Q2 to Q3 levels of plasma VA/triglyceride(TG)have decreased risk of T2DM(odds ratio(OR)Q2=0.68,PQ2=0.021;ORQ3=0.59,PQ3＜0.01).Our results indicated that the imbalance of circulating lipids and VA might affect the relationship between VA and T2DM.The middle and aging subjects with higher ratios of plasma VA/TC,VA/HDL-c,and VA/LDL-c displayed increased risk for T2DM,but the moderate ratio of VA/TG might protect against risk of T2DM.

Type 2 diabetes mellitusVitamin ALipidNutritionDisease prevention

Pengfei Li、Jingjing Xu、Yujie Guo、Xiaojun Ma、Shaobo Zhou、Chi Zhang、Huiyan Yu、Ying Wang、Xixiang Wang、Linhong Yuan

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School of Public Health,Beijing Key Laboratory of Environmental Toxicology,China-British Joint Laboratory of Nutrition Prevention and Control of Chronic Diseases,Capital Medical University,Beijing 100069,China

School of Science,Faculty of Engineering and Science,University of Greenwich,Chatham ME4 4TB,UK

School of Biological Sciences,University of Nebraska-Lincoln,NE 68588-0660,USA

Suzhou Hospital,Affiliated Hospital of Medical School,Nanjing University,Suzhou 215153,China

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国家自然科学基金国家自然科学基金Beijing High-level Public Health Technical Personnel Training Program

82173508819730272022-3-032

2024

10.26599/FSHW.2022.9250173

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(4)
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