首页|Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

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Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China.Interestingly,our previous work has found that R.crenulate extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced colitis.Thus,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against colitis.The chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were identified.Meanwhile,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds.The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis.The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid metabolism.Correspondingly,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

Rhodiola crenulateColitisChemical characterizationPlasma pharmacochemistryMetabolomics

Yu Peng、Xiaoao Xiao、Tingting Ji、Xinyuan Wang、Yixuan Xu、Jianbo Xiao、Hui Cao、Zhiyong Chen、Huifan Liu、Yuanaing Gao、Honexun Tao

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Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University Nanjing 211166,China

School of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,China

Department of Analytical Chemistry and Food Science,Faculty of Science,University of Vigo,Vigo 36310,Spain

CISPAC,Fontan Building,City of Culture,Santiago de Compostela 15707,Spain

Shaanxi Academy of Traditional Chinese Medicine,Xi'an 710003,China

Guangdong Key Laboratory of Science and Technology of Lingnan Specialty Food,Zhongkai University of Agriculture and Engineering,Guangzhou 510550,China

State Key Laboratory of Southwestern Chinese Medicine Resources,Chengdu 610075,China

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中国博士后科学基金Nanjing Medical University Science and Technology Development FundJiangsu Provincial Outstanding Postdoctoral Programme国家自然科学基金国家自然科学基金Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine ResourcesGuangdong Provincial Key Laboratory of Lingnan Specialty Food Science and TechnologyZhejiang Province Key Laboratory of Medical Electronics and Digital Health

2021M701759NMUB202100122022ZB4308187365482201579SKLTCM2022020kjzr220009MEDH2022016

2024

10.26599/FSHW.2022.9250176

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(4)
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