Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics

Yu Peng ¹Xiaoao Xiao ¹Tingting Ji ¹Xinyuan Wang ¹Yixuan Xu ¹Jianbo Xiao ²Hui Cao ³Zhiyong Chen ⁴Huifan Liu ⁵Yuanaing Gao ¹Honexun Tao⁶

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作者信息

1. Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University Nanjing 211166,China
2. School of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,China;Department of Analytical Chemistry and Food Science,Faculty of Science,University of Vigo,Vigo 36310,Spain;CISPAC,Fontan Building,City of Culture,Santiago de Compostela 15707,Spain
3. Department of Analytical Chemistry and Food Science,Faculty of Science,University of Vigo,Vigo 36310,Spain;CISPAC,Fontan Building,City of Culture,Santiago de Compostela 15707,Spain
4. Shaanxi Academy of Traditional Chinese Medicine,Xi'an 710003,China
5. Guangdong Key Laboratory of Science and Technology of Lingnan Specialty Food,Zhongkai University of Agriculture and Engineering,Guangzhou 510550,China
6. School of Food and Biological Engineering,Jiangsu University,Zhenjiang 212013,China;State Key Laboratory of Southwestern Chinese Medicine Resources,Chengdu 610075,China
折叠

Abstract

Rhodiola crenulate is the edible medicinal herbal medicine widely used for altitude sickness in China.Interestingly,our previous work has found that R.crenulate extract(RCE)could significantly improve the pathology associated with dextran sulfate sodium-induced colitis.Thus,the current research aims to reveal the pharmacodynamic material basis of RCE,as well as its mechanism against colitis.The chemical characterization of RCE was performed by UHPLC-HR-MS,through which a total of 88 constituents were identified.Meanwhile,our results also found 29 constituents absorbed into blood and 8 metabolized absorbable compounds.The decreased flavonoids prototype and the elevated sulfated products of phenols were observed under pathophysiological conditions of colitis.The metabolomics study revealed that colitis caused the alternation of fatty acid metabolism,steroid hormone biosynthesis and bile acid metabolism.Correspondingly,RCE could prevent colitis by improving fatty acid metabolism and secondary bile acid metabolism.

Key words

Rhodiola crenulate/Colitis/Chemical characterization/Plasma pharmacochemistry/Metabolomics

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基金项目

中国博士后科学基金(2021M701759)

Nanjing Medical University Science and Technology Development Fund(NMUB20210012)

Jiangsu Provincial Outstanding Postdoctoral Programme(2022ZB430)

国家自然科学基金(81873654)

国家自然科学基金(82201579)

Open Research Fund of State Key Laboratory of Southwestern Chinese Medicine Resources(SKLTCM2022020)

Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology(kjzr220009)

Zhejiang Province Key Laboratory of Medical Electronics and Digital Health(MEDH2022016)

出版年

2024

食品科学与人类健康(英文)

CSTPCDCSCD

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