首页|Lactiplantibacillus plantarum AR1 13 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat
Lactiplantibacillus plantarum AR1 13 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat
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Stroke is one of the leading causes of death and disability worldwide.However,information on stroke-related tongue coating microbiome(TCM)is limited,and whether TCM modulation could benefit for stroke prevention and rehabilitation is unknown.Here,TCM from stroke patients(SP)was characterized using molecular techniques.The occurrence of stroke resulted in TCM dysbiosis with significantly reduced species richness and diversity.The abundance of Prevotella,Leptotrichia,Actinomyces,Alloprevotella,Haemophilus,and TM7_[G-1]were greatly reduced,but common infection Streptococcus and Pseudomonas were remarkably increased.Furthermore,an antioxidative probiotic Lactiplantibacillus plantarum AR1 13 was used for TCM intervention in stroke rats with cerebral ischemia/reperfusion(I/R).AR113 partly restored I/R induced change of TCM and gut microbiota with significantly improved neurological deficit,relieved histopathologic change,increased activities of antioxidant enzymes,and decreased contents of oxidative stress biomarkers.Moreover,the gene expression of antioxidant-related proteins and apoptosis-related factors heme oxygenase-1(HO-1),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),nuclear factor erythroid 2-related factor 2(Nrf2),NAD(P)H:quinone oxidoreductase-1(NQO-1),and Bcl-2 was significantly increased,but cytochrome C,cleaved caspase-3,and Bax were markedly decreased in the brain by AR1 13 treatment.The results suggested that AR1 13 could ameliorate cerebral I/R injury through antioxidation and anti-apoptosis pathways,and AR1 13 intervention of TCM may have the application potential for stroke prevention and control.
Zhiqiang Xiong、Gang Liu、Ling Fang、Xiuming Li、Yongjun Xia、Guangqiang Wang、Xin Song、Lianzhong Ai
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Shanghai Engineering Research Center of Food Microbiology,School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China
Department of Rehabilitation,Huashan Hospital,Fudan University,Shanghai 200040,China
Department of Rehabilitation Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
国家杰出青年科学基金Shanghai Education Committee Scientific Research Innovation ProjectClinical research project in health industry of Shanghai Municipal Health CommissionDevelopment Fund for Shanghai Talents
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