Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

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外文摘要：High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution.Extra-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of maturity.Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling cascades.In this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

外文关键词：

CancerNutrigenomicsSignalingApoptosisAllium sativum

作者：

Ammad Ahmad Farooqi、Iqra Mobeen、Rukset Attar、Khalida I.Noel、Baojun Xu、William C.Cho

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作者单位：

Institute of Biomedical and Genetic Engineering(IBGE),Islamabad 44000,Pakistan

Khursheed Rasheed Hospital Lahore,Lahore 53720,Pakistan

Department of Obstetrics and Gynecology,Yeditepe University,Ataşehir 34755,Turkey

Human Anatomy Department,College of Medicine,Al-Mustansiriyah University,Baghdad 10036,Iraq

Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai 519087,China

Department of Clinical Oncology,Queen Elizabeth Hospital,Hong Kong G51 4TF,China

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基金：

BNU-HKBU United International College

项目编号：

UICR202107

出版年：

2024

DOI：

10.26599/FSHW.2022.9250196

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(5)