Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

Ammad Ahmad Farooqi ¹Iqra Mobeen ²Rukset Attar ³Khalida I.Noel ⁴Baojun Xu ⁵William C.Cho⁶

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作者信息

1. Institute of Biomedical and Genetic Engineering(IBGE),Islamabad 44000,Pakistan
2. Khursheed Rasheed Hospital Lahore,Lahore 53720,Pakistan
3. Department of Obstetrics and Gynecology,Yeditepe University,Ataşehir 34755,Turkey
4. Human Anatomy Department,College of Medicine,Al-Mustansiriyah University,Baghdad 10036,Iraq
5. Food Science and Technology Program,Department of Life Sciences,BNU-HKBU United International College,Zhuhai 519087,China
6. Department of Clinical Oncology,Queen Elizabeth Hospital,Hong Kong G51 4TF,China
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Abstract

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution.Extra-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of maturity.Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling cascades.In this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

Key words

Cancer/Nutrigenomics/Signaling/Apoptosis/Allium sativum

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基金项目

BNU-HKBU United International College(UICR202107)

出版年

2024

食品科学与人类健康(英文)

CSTPCDCSCD

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参考文献量125

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