首页|Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats
Oral administration of egg white ovotransferrin prevents osteoporosis in ovariectomized rats
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Ovotransferrin,an iron-binding glycoprotein,accounting for approximately 12%of egg white protein,is a member of transferrin family.Our previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts,while inhibits osteoclastogenesis and resorption activity.The work aims to study the efficacy of orally administered ovotransferrin on the prevention of osteoporosis using ovariectomized(OVX)Sprague-Dawley rats.Oral administration of ovotransferrin showed no negative effect on body weight,food intake and organ weight.After 12-week treatment,feeding ovotransferrin at a dose of 1%(1 g ovotransferrin/100 g diet)prevented OVX-induced bone loss and maintained relatively high bone mineral density and integrated bone microarchitecture.The serum concentration of biomarkers indicating bone formation was increased in ovotransferrin administration groups,while the bone resorption biomarkers were decreased.Ovotransferrin feeding also decreased the production of serum cytokine TNF-α and IL-6,which are two stimulators for osteoclast differentiation.In addition to its direct regulatory role on bone turnover,ovotransferrin supplementation might benefit osteoporosis prevention by inhibiting adipogenesis,and regulating immune response.Our results suggested the potential application of ovotransferrin as a functional food ingredient on the prevention of osteoporosis.
OvotransferrinOvariectomized(OVX)ratsBone mineral densityBone microarchitectureBone resorptionInflammation
Nan Shang、Xiaoyu Bao、Michael Doschak、Jianping Wu
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Department of Agricultural,Food and Nutritional Science,University of Alberta,Edmonton T6G 2P5,Canada
College of Engineering,China Agricultural University,Beijing 100083,China
Key Laboratory of Precision Nutrition and Food Quality,Department of Nutrition and Healthy,China Agricultural University,Beijing 100193,China
Faculty of Pharmacy&Pharmaceutical Sciences,University of Alberta,Edmonton T6G 2H5,Canada
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Egg Farmers of Canada,Global Egg CorpNatural Sciences and Engineering Research Council of Canada(NSERC)Chinese Scholarship Council(CSC)Alberta Innovates Technology Futures(AITF)
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