Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

Rong Yuan ¹Qiqi Xin ¹Weili Shi ¹Yu Miao ¹Zhengchuan Zhu ²Yahui Yuan ¹Ying Chen ³Xiaoning Chen ⁴Sean Xiao Leng ⁵Keji Chen ¹Weihong Cong¹

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作者信息

1. Cardiovascular Diseases Laboratory,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;National Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China
2. National Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China
3. School of Health Economics and Management,Nanjing University of Chinese Medicine,Nanjing 210023,China
4. Department of Otolaryngology,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China
5. Division of Geriatric Medicine and Gerontology,Department of Medicine,Johns Hopkins University School of Medicine,Baltimore 21224,United States
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Abstract

Atherosclerosis remains a great threat to human health worldwide.Previous studies found that tetramethylpyrazine(TMP)and paeoniflorin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in vitro.However,whether TMP-PF improves atherosclerosis in vivo needs further exploration.The present study aims to assess the anti-atherosclerotic properties of TMP-PF in ApoE-/-mice and explore the related molecule mechanisms.Results showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels,suppressed vascular endothelial growth factor receptor 2(VEGFR2)and nuclear receptor subfamily 4 group A member 1(NR4A1)expression in aortic tissues,inhibited plaque angiogenesis,reduced plaque areas,and alleviated atherosclerosis in ApoE-/-mice.Also,TMP-PF exhibited a better modulation effect than TMP or PF alone.However,NR4A1 agonist abolished the anti-atherosclerotic effects of TMP-PF.In conclusion,TMP-PF was first found to alleviate atherosclerosis progression by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway,indicating that TMP-PF had a positive effect on reducing hyperlipemia and attenuating atherosclerosis development.

Key words

Atherosclerosis/Hyperlipemia/Angiogenesis/Plaque stability/Chinese medicine/Tetramethylpyrazine/Paeoniflorin

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基金项目

Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ11-061)

Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ14-YQ-007)

National Natural Science Foundation of China(82004193)

CACMS Innovation Fund(CI 2021A00914)

Irma and Paul Milstein Program for Senior Health of Milstein Medical Asian American Partnership Foundation()

出版年

2024

食品科学与人类健康(英文)

CSTPCD

ISSN：

段落导航