食品科学与人类健康(英文)2024，Vol.13Issue(5) ：2799-2812.DOI:10.26599/FSHW.2022.9250227

Amelioration of dextran sodium sulphate-induced colitis in mice by treatment with Lactobacillus rhamnosus and Lactobacillus reuteri:intraspecific and interspecific patterns

Chunxiu Lin Yuxing Zheng Bo Zhang Guopeng Lin Kexin Shang Jianxin Zhao Gang Wang Wei Chen
食品科学与人类健康(英文)2024，Vol.13Issue(5) ：2799-2812.DOI:10.26599/FSHW.2022.9250227
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Amelioration of dextran sodium sulphate-induced colitis in mice by treatment with Lactobacillus rhamnosus and Lactobacillus reuteri:intraspecific and interspecific patterns

Chunxiu Lin 1Yuxing Zheng 1Bo Zhang 1Guopeng Lin 1Kexin Shang 2Jianxin Zhao 3Gang Wang 3Wei Chen2
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作者信息

  • 1. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China
  • 2. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China
  • 3. State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China;(Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China
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Abstract

Lactobacillus rhamnosus(Rh)and Lactobacillus reuteri(Re)are well-known probiotic species in inflammatory bowel disease(IBD)research.The variations between these species'efficacy against colitis,and their model of action in this regard,are intriguing and enable treatment to be individually tailored to patients.In this study,four strains each of Rh and Re were isolated from fecal samples and their draft genomes were sequenced.The anti-colitis activities of both strains involved various aspects of intestinal immune,physical,chemical,and biological barrier function.Strikingly,the tested strains exhibited considerable interspecies and intraspecies specificity in colitis amelioration.Rh strains significantly outperformed Re strains in terms of short-chain fatty acid synthesis.Nevertheless,Re strains were more effective than Rh strains in inhibiting production of inflammatory factors;promoting production of intestinal mucus,antimicrobial peptides,and tight junction proteins;and supporting the stem cell compartment.This accounts for the anti-colitis outcomes of Re strains being superior to those of Rh strains.In addition,the effective Rh and Re strains were found to express high concentrations of specific carbohydrate metabolism-and prophage-related genes,respectively.Taken together,the results of this study could assist researchers in developing effective therapies for IBD.

Key words

Inflammatory bowel disease/Anti-colitis/Lactobacillus rhamnosus/Lactobacillus reuteri/Intestinal barrier function/Short-chain fatty acids

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基金项目

National Natural Science Foundation of China(32021005)

National Natural Science Foundation of China(31820103010)

Fundamental Research Funds for the Central Universities(JUSRP22006)

Fundamental Research Funds for the Central Universities(JUSRP51501)

Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province,Postgraduate Research&Prac(KYCX22_2391)

出版年

2024
食品科学与人类健康(英文)

食品科学与人类健康(英文)

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