Improvement of glucose metabolism in middle-aged mice on a high-fat diet by whole-grain highland barley is related to low methionine levels

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外文摘要：Methionine restriction(MR)is an effective dietary strategy to regulate energy metabolism and alleviate oxidative stress and inflammation in the body,especially in the middle-aged and elderly population.However,the high methionine content of meat products makes this dietary strategy impossible to combine with protein supplementation and MR.Highland barley(HB),a low-methionine cereal,not only provides the body with protein but also has improved glucose metabolism and antioxidant and anti-inflammatory properties.Therefore,this study evaluated the feasibility of HB as a source of methionine-restricted dietary protein and the potential mechanisms.Middle-aged C57BL/6J mice were fed a control diet(CON),a high-fat diet(HFD),a whole-grain HB high-fat diet(HBHF),or a HBHF+methionine diet(HBHFmet)for 25 weeks.The results showed that the HBHF could keep the body weight,fasting glucose,insulin,homeostasis model assessment of insulin resistance(HOMA-IR),blood lipids,inflammation,and oxidative stress of HFD mice at normal levels.Compared with the HFD groups,HBHF inhibited pancreatic cell apoptosis and improved insulin secretion while improving hepatic and skeletal muscle glucose metabolism.However,these efficacies were attenuated in HBHFmet group mice.These findings suggest that HBHF has an MR strategy.

外文关键词：

Methionine restriction strategyHighland barleyInsulin secretionGlucose metabolism

作者：

Chuanxing Feng、Yueting Ge、Bowen Li、Xiangrong Cheng、Xue Tang、Jianjin Zhu、Yuge Jiang、Yonghui Shi、Guowei Le

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作者单位：

Center for Food Nutrition and Functional Food Engineering,School of Food Science and Technology,Jiangnan University,Wuxi 214122,China

State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China

College of Life Science,xinyang Normal University,xinyang 464000,China

Key Laboratory of xin'an Medicine,Ministry of Education,Anhui Province Key Laboratory of R&D of Chinese Medicine,Anhui University of Chinese Medicine,Hefei 230038,China

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基金：

12th Five-Year Plan for Science and Technology Development of China

项目编号：

2012BAD33B05

出版年：

2024

DOI：

10.26599/FSHW.2022.9250235

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(5)