首页|Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator

Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator

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Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a"disease".Brown adipose tissue(BAT)thermogenesis and white adipose tissue(WAT)browning emerge as a potential strategy of anti-obesity by dissipating energy as heat.However,drugs based on adipose tissue thermogenesis have not been successfully approved yet.In current study,we found that black tea extract(BTE)obtained by patent-authorized manufacturing process prevented body weight gain as novel thermogenic activator with reduction of adiposity,improvement of adipose distribution,and glucose metabolism improvement in diet-induced obesity mice.Mechanismly,anti-obesity effect of BTE depends on promoting BAT thermogenesis and WAT browning with upregulation of uncoupling protein 1(UCP1),especially visceral adipose tissue(VAT)with browning resistance.Specifically,utilizing in silico approach of network pharmacology and molecular docking,we identified carbonic anhydrase 2(CA2)in nitrogen metabolism as anti-obesity target of BTE and further elucidated that protein kinase B(AKT)signaling pathway linked CA2 and UCP1.Meanwhile gut microbiota regulation may prompt the CA2-dependent thermogenesis activation.Our findings demonstrated anti-obesity effect of BTE as thermogenic activator through CA2-mediated BAT thermogenesis and WAT browning via CA2-AKT-UCP1 signaling pathway,which could be developed as promising anti-obesity agent with good safety and efficacy.

ObesityBlack teaThermogenesisBrowningAdipose tissue

Peng Ma、Jie Xiao、Biyu Hou、Ping He、Xinyu Yang、Yisa Wang、Zijing Wang、Tianshu Xu、Xiuying Yang、Xuan Zhu、Shasha Xiang、Song Li、Guanhua Du、Jian Ying、Guifen Qiang

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State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research,Beijing 100050,China

COFCO Nutrition and Health Research Institute,Beijing 102209,China

Department of Pharmacy,The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518000,China

Faculty of Biology,Medicine and Health Sciences,The University of Manchester,Manchester M13 9PL,United Kingdom

Changchun University of Chinese Medicine,Changchun 130117,China

School of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou 310018,China

China Tea Technology(Beijing)Co.,Ltd.,Beijing 102209,China

Beijing Key Laboratory of Nutrition,Health and Food Safety,Beijing 102209,China

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National Natural Science Foundation of ChinaCAMS Innovation Fund for Medical Sciences(CIFMS)CAMS Innovation Fund for Medical Sciences(CIFMS)National High Technology Research and Development Program of China

NSFC 820708772022-I2M-JB-0102021-I2M-1-0052017YFE0112900

2024

10.26599/FSHW.2022.9250236

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(5)