首页|Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model

Capsaicin alleviates the hepatic clock gene disruption and gut microbiota dysbiosis in circadian rhythm disorder mouse model

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As the body's internal clock,the circadian rhythm regulates the energy expenditure,appetite,and sleep.There exists a close relationship between the host circadian rhythm and gut microbiota.In this work,a circadian disorder mouse model induced by constant darkness(CD)was constructed to investigate the regulating effects of capsaicin(CAP)on disturbances of metabolism homeostasis and gut microbiota in the respect of circadian rhythm-related mechanisms.Our results indicated that CAP reduced weight gain induced by circadian rhythm disorder in mice by inhibiting fat accumulation in liver and adipose tissue.The rhythmic expressions of circadian clock genes and lipid-metabolism related genes in liver were also recovered by CAP.Microbial study using 16S rRNA sequencing revealed that CAP modulated the gut microbiota richness,diversity and composition,and restored diurnal oscillations of gut microbes at the phylum and family level.These results indicated that CAP could alleviate CD-induced hepatic clock gene disruption and gut microbiota dysbiosis in mice,providing theoretical basis for CAP to be used as a muti-functional ingredient with great health-promoting effects.

CapsaicinCircadian rhythmHepatic clock geneGut microbiotaLipid dysregulation

Bolin Lin、Chi-Tang Ho、Yawen Wang、Jie Xiao、Muwen Lu

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Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods,College of Food Science,South China Agricultural University,Guangzhou 510642,China

Department of Food Science,Rutgers University,New Brunswick 08901,USA

Department of Hematology,The Hospital Affiliated to Qingdao University,Qingdao 266000,China

Program for Guangdong Introducing Innovative and Entrepreneurial TeamsScience and Technology Program of Guangzhou,ChinaGuangdong Basic and Applied Basic Research Foundation

2019ZT08N2912023A04J07602024A1515030058

2024

10.26599/FSHW.2022.9250238

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(5)