Comparative genomic analysis revealed that dietary habits affected the adaptation of Bifidobacterium bifidumto the intestinal tract in different geographic populations

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外文摘要：Recent research on the genome of Bifidobacterium bifidum has mainly focused on the isolation sources(intestinal tract niche)recently,but reports on the isolation region are limited.This study analyzed the differences in the genome of B.bifidum isolated from different geographical populations by comparative genomic analysis.Results at the genome level indicated that the GC content of American isolates was significantly higher than that of Chinese and Russian isolates.The phylogenetic tree,based on 919 core genes showed that B.bifidum might be related to the geographical characteristics of isolation region.Furthermore,functional annotation analysis demonstrated that copy numbers of carbohydrate-active enzymes(CAZys)involved in the degradation of polysaccharide from plant and host sources in B.bifidum were high,and 18 CAZys showed significant differences across different geographical populations,indicating that B.bifidum had adapted to the human intestinal environment,especially in the groups with diets rich in fiber.Dietary habits were one of the main reasons for the differences of B.bifidum across different geographical populations.Additionally,B.bifidum exhibited high diversity,evident in glycoside hydrolases,the CRISPR-Cas system,and prophages.This study provides a genetic basis for further research and development of B.bifidum.

外文关键词：

Bifidobacterium bifidumComparative genomicsGenetic diversityAdaptationCarbohydrate-active enzymes

作者：

Min Li、Jie Yu、Weicheng Li、Qiong Wu、Jiaqi Sun、Zhihong Sun

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作者单位：

Key Laboratory of Dairy Biotechnology and Engineering,Inner Mongolia Agricultural University,Ministry of Education,Inner Mongolia Agricultural University,Hohhot 010018,China

Key Laboratory of Dairy Products Processing,Ministry of Agriculture and Rural Affairs,Inner Mongolia Agricultural University,Hohhot 010018,China

Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering,Inner Mongolia Agricultural University,Hohhot 010018,China

Collaborative Innovative Center for Lactic Acid Bacteria and Fermented Dairy Products,Ministry of Education,Inner Mongolia Agricultural University,Hohhot 010018,China

Center for Applied Mathematics Inner Mongolia,Hohhot 010018,China

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基金：

National Key R&D Program of ChinaNational Natural Science Foundation of ChinaInner Mongolia Science&Technology planning projectearmarked fund for CARS36

项目编号：

2022YFD21007002323250402022YFSJ0017

出版年：

2024

DOI：

10.26599/FSHW.2022.9250243

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(5)