Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation

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外文摘要：Inflammatory stimulation plays a significant role in the development and worsening of insulin-resistant diabetes.Therefore,it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation.Here,we present evidence that Bakuchiol(BL),a monoterpene phenolic compound first discovered from Psoralea corylifolia L.as traditional Chinese medicine,can effectively improve insulin resistance in diabetic mice through anti-inflammation.Our findings demonstrate that BL alleviates inflammation by inhibiting the toll-like receptor 4/nuclear factor KB/mitogen-activated protein kinase axis,consequently enhancing insulin receptor signaling through the c-Jun N-terminal kinase/suppressors of cytokine signaling 3/insulin receptor substratel pathway and improving glucolipid homeostasis.Furthermore,the insulin recovery achieved with BL(60 mg/kg)was comparable to that of metformin(200 mg/kg).These results provide further support for considering BL as a potential treatment option for insulin-resistant diabetes mellitus.

外文关键词：

BakuchiolDiabetesInsulin resistanceProteomicInflammation

作者：

Zhenhua Liu、Xiaoqing Xu、Zhenhua Liang、Yixiao Chen、Qiuyi Wang、Wenyi Kang、Yan Zhang、Bin Cong

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作者单位：

National R&D Center for Edible Fungus Processing Technology,Henan University,Kaifeng 475004,China

Joint International Research Laboratory of Food & Medicine Resource Function,Kaifeng 475004,China

College of Agriculture,Henan University,Kaifeng 475004,China

Shenzhen Research Institute of Henan University,Shenzhen 518000,China

Hebei Key Laboratory of Forensic Medicine,College of Forensic Medicine,Hebei Medical University,Shijiazhuang 050017,China

Hebei Food Safety Key Laboratory,Hebei Food Inspection and Research Institute,Shijiazhuang 050091,China

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出版年：

2024

DOI：

10.26599/FSHW.2023.9250052

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(6)