Microbial phenolic metabolites are associated with better frontal lobe cognition

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外文摘要：With increasing life expectancy,neurodegenerative diseases have become one of the leading causes of ill-health in the elderly.Preventive strategies include following healthy diets,such as the Mediterranean diet,which is particularly rich in polyphenols,bioactive compounds with neuroprotective properties.The aim of this study was to assess the association of microbial phenolic metabolites(MPM)with cognition.This cross-sectional analysis was performed with 200 participants of the PREDIMED trial(Barcelona-Clinic recruitment center).A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM(protocatechuic acid,enterodiol glucuronide,enterolactone glucuronide,urolithin B glucuronide,and vanillic acid glucuronide),and cognitive function was evaluated with neuropsychological tests.Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM,and a score was calculated as the weighted sum of MPM.A higher MPM score was associated with better frontal lobe function.Among individual metabolites,vanillic acid glucuronide was correlated with frontal cognitive performance.Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2.A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

外文关键词：

PolyphenolsNeurodegenerationMicrobiotaGut-brain axisPREDIMED

作者：

Inés Domínguez-López、Isabella Parilli-Moser、Anna Vallverdú-Queralt、Anna Tresserra-Rimbau、Cinta Valls-Pedret、Zenaida Vázquez-Ruiz、Olga Castañer、Ramon Estruch、Emili Ros、Rosa M.Lamuela-Raventós

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作者单位：

Departament de Nutrició,Ciències de l'Alimentació i Gastronomía,Facultat de Farmacia,Universitat de Barcelon(UB),Barcelona 08028,Spain

Institut de Nutrició i Seguretat Alimentària(INSA),Universitat de Barcelona(UB),Santa Coloma de Gramanet 08034,Spain

CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN),Instituto de Salud Carlos Ⅲ,Madrid 28029,Spain

Lipid Clinic,Endocrinology and Nutrition Service,Institut d'Investigacions Biomèdiques August Pi i Sunyer,Hospital Clínic,Barcelona 08036,Spain

Department of Preventive Medicine and Public Health,University of Navarra,IdiSNA,Pamplona 31008,Spain

Unit of Cardiovascular Risk and Nutrition,Institut Hospital del Mar de Investigaciones Médicas(IMIM),Barcelona 08007,Spain

Department of Internal Medicine,Hospital Clinic,Institut d'Investigació Biomèdica August Pi i Sunyer(IDIBAPS),University of Barcelona,Barcelona 08007,Spain

Department of Endocrinology,Hospital Clinic IDIBAPS,Barcelona 08007,Spain

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出版年：

2024

DOI：

10.26599/FSHW.2023.9250013

食品科学与人类健康(英文)

CSTPCD

ISSN：

年,卷(期)：2024.13(6)