首页|Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers

Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers

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Krill oil(KO)exhibits various biological activities,such as anti-inflammatory and antitumor effects.However,the inhibitory effects of benign prostatic hyperplasia(BPH)in vitro and in vivo have not yet been studied.This study investigated the anti-BPH effects of KO extracted by an enzymatic hydrolysis method.KO treatment inhibited the proliferation of WMPY-1 and BPH-1 cells by induction of G0/G1 phase arrest through the modulation of positive and negative regulators in both prostate cell types.KO treatment stimulated phosphorylation of c-Jun N-terminal kinase(JNK)and p38 signaling.In addition,KO changed the expression of BPH-related markers(5α-reductase,androgen receptor,FGF,Bcl-2,and Bax)and the activity of the proliferation-mediated NF-κB binding motif.KO-induced levels of proliferation-mediated molecules of prostate cells were attenuated in the presence of siRNA-specific p-38(si-p38)and JNK(si-JNK).Furthermore,the administration of KO alleviated prostate size and weight and the cell layer thickness of prostate glands in a testosterone enanthate-induced BPH rat model.KO treatment altered the level of dihydrotestosterone in serum and the expression levels of BPH-related markers in prostate tissues.Finally,KO-mediated inhibition of prostatic growth was validated by histological analysis.These results suggest that KO has an inhibitory effect on BPH in prostate cells in vitro and in vivo.Thus,KO might be a potential prophylactic or therapeutic agent for patients with BPH.

ProliferationG0/G1-phase cell cycleNF-κBDihydrotestosterone

Hoon Kim、Jongyeob Kim、Byungdoo Hwang、Sang Yong Park、Ji-Yeon Shin、Eun Byeol Go、Jae Sil Kim、Youngjin Roh、Soon Chul Myung、Seok-Joong Yun、Yung Hyun Choi、Wun-Jae Kim、Sung-Kwon Moon

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Department of Food and Nutrition,Chung-Ang University,Anseong 17546,Republic of Korea

SD Biotechnologies,Seoul 07793,Republic of Korea

Department of Urology,College of Medicine,Chung-Ang University,Seoul 06974,Republic of Korea

Department of Urology,Chungbuk National University,Chungbuk 361-763,Republic of Korea

Department of Biochemistry,College of Oriental Medicine,Dongeui University,Busan 47340,Republic of Korea

Institute of Urotech,Cheongju,Chungcheongbuk-do 361-763,Republic of Korea

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2024

10.26599/FSHW.2023.9250017

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(6)