Polysaccharide-rich extract of Potentilla anserina ameliorates nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/sugar diet-fed mice

Xiujun Lin ¹Yimei Zheng ²Yingying Yan ³Hongting Deng ¹Shunxin Wang ¹Yuanju He ¹Yuting Tian ⁴Wenhui Zhang ³Hui Teng¹

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作者信息

1. Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Guangdong Province Engineering Laboratory for Marine Biological Products,Guangdong Provincial Engineering Technology Research Center of Seafood,Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524088,China
2. Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Guangdong Province Engineering Laboratory for Marine Biological Products,Guangdong Provincial Engineering Technology Research Center of Seafood,Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524088,China;College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China
3. Institute of Agricultural Products Processing & Food Science,Tibet Academy of Agricultural and Animal Husbandry Sciences,Lhasa 850002,China
4. College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China
折叠

Abstract

Potentilla anserina L.(PA)belongs to the Rosaceae family,is a common edible plant in the Qinghai-Tibet Plateau areas of China.This study elucidates the mechanism upon which crude polysaccharide of PA(PAP)on fat accumulation in HepG2 cells stimulated by oleic acid(OA)and high fat high sugar induced mice.The result revealed that PAP inhibited lipid accumulation in obese mice and ameliorated the degree of damage in OA-induced HepG2 cells.Specifically,compared to the control group,the TG and TC levels were decreased in cells and mice serum,the aspartate transaminase and alamine aminotransferase contents were declined in liver of obese mice by PAP treatment.The expressions of adipogenic genes of SREBP-1c,C/EBPα,PPARγ,and FAS were inhibited after PAP treatment.Moreover,PAP increased the mRNA levels of CPT-1 and PPARα,which were involved in fatty acid oxidation.The present results indicated the PAP could alleviate the damage of liver associated with obesity and PAP treatment might provide a dietary therapeutic option for the treatment of hyperlipidemia.

Key words

Potentilla anserina L./Non-alcoholic fatty liver disease/Lipid accumulation/HepG2 cells/High fat diet

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出版年

2024

食品科学与人类健康(英文)

CSTPCDCSCD

ISSN：

段落导航