首页|Application of solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS)in resolution of metabolism pattern of higher alcohols in rat plasma

Application of solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS)in resolution of metabolism pattern of higher alcohols in rat plasma

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Higher alcohols are key factors affecting sensory quality and post-drinking comfort of alcoholic beverages.A strategy combining solid-phase extraction and gas chromatography-mass spectrometry(SPE-GC-MS)was established to analyze the metabolism pattern of higher alcohols in rat plasma after gavage of 4 common alcoholic beverages including huangjiu,baijiu,wine and brandy.7 mL of dichloromethane was determined as the optimal extraction condition,and 8 higher alcohols were precisely quantified with detection limits of 1.82-11.65 pg/L,recoveries of 89.07％-110.89％and fine repeatability.The fastest absorption and elimination rates of plasma total higher alcohols were observed in baijiu and huangjiu group,respectively,and the highest peak concentration was found in brandy group.Additionally,the metabolic rate of plasma isoamyl alcohol in huangjiu group was faster than that in wine group at the same intragastric administration dosage.This study may provide potential insight for evaluation of alcoholic beverage quality.

Higher alcoholsAlcoholic beveragesSPE-GC-MSPharmacokinetic parameters

Yufei Liu、Xiaonian Cao、Zhilei Zhou、Qingxi Ren、Zhongwei Ji、Min Gong、Yuezheng Xu、Weibiao Zhou、Shuguang Chen、Jian Mao

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National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing,School of Food Science and Technology,Jiangnan University,Wuxi 214122,China

Jiangsu Provincial Engineering Research Center for Bioactive Product Processing,Jiangnan University,Wuxi 214122,China

Luzhou Laojiao Co.,Ltd.,Luzhou 646000,China

Shaoxing Key Laboratory of Traditional Fermentation Food and Human Health,Jiangnan University(Shaoxing)Industrial Technology Research Institute,Shaoxing 312000,China

National Engineering Research Center for Huangjiu,Zhejiang Guyuelongshan Shaoxing Wine Co.,Ltd.,Zhejiang Shaoxing Huangjiu Industry Innovation Service Complex,Shaoxing 312000,China

Department of Food Science and Technology,National University of Singapore,Singapore 117542,Singapore

Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College(CAMS & PUMC),Beijing 100730,China

National Engineering Research Center for Huangjiu,Zhejiang Guyuelo

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2024

10.26599/FSHW.2023.9250033

食品科学与人类健康(英文)

食品科学与人类健康(英文)

CSTPCD
ISSN：
年,卷(期)：2024.13(6)