首页|Edible prodelphinidins that improve postprandial hyperglycemia were discovered in Chinese bayberry(Myrica rubra Sieb.et Zucc.)fruits
Edible prodelphinidins that improve postprandial hyperglycemia were discovered in Chinese bayberry(Myrica rubra Sieb.et Zucc.)fruits
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Edible prodelphinidins that improve postprandial hyperglycemia were discovered in Chinese bayberry(Myrica rubra Sieb.et Zucc.)fruits
Plant polyphenols are potential substitutes for clinical α-glucosidase inhibitors.Our previous studies indicated that prodelphinidins from Chinese bayberry leaves(BLPs)have stronger α-glucosidase inhibitory activity than other common polyphenols,but they have no safe history of consumption.There is a reasonable prospect that prodelphinidins from Chinese bayberry fruits(BFPs)can improve postprandial hyperglycemia,though known active components are only myricetin and cyanidin-3-O-glucoside.Hence,the aim of this study was to analyze structure and hypoglycemic effect of BFPs of"Biqi"(BQPs)and"Dongkui"(DKPs)cultivars,and compare their difference with BLPs.The contents of BQPs and DKPs were(221.73±0.60)and(136.82±4.33)mg epicatechin(EC)equivalents/g dry weight,respectively.The most subunits were epigallocatechin gallate along with a small amount of epigallocatechin,epicatechin gallate and EC connected by B-type linkages and a small portion of A-type linkages with mean polymerization degree of 4.25 and 4.08,respectively.Importantly,BQPs and DKPs were α-glucosidase inhibitors with half inhibitory concentration of 11.91 and 9.47 μg/mL respectively,which were significantly stronger than BLPs.DKPs could also improve postprandial hyperglycemia of normal mice and high fat diet-induced type Ⅱ diabetic mice.Therefore,edible prodelphinidins,which have stronger hypoglycemic effect than BLPs,were first found in Chinese bayberry fruits.
Chinese bayberry fruitProdelphinidinsStructureα-GlucosidasePostprandial hyperglycemia
Yi Wang、Laiming Zhang、Jiaxiong Wu、Chengxiao Yu、Xingqian Ye、Haibo Pan、Shiguo Chen
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College of Biosystems Engineering and Food Science,National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment,Zhejiang Key Laboratory for Agro-food Processing,Integrated Research Base of Southern Fruit and Vegetable Preservation Technology,Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control,Zhejiang University,Hangzhou 310058,China
Ningbo Research Institute,Zhejiang University,Ningbo 315100,China
Zhejiang Univers
Innovation Center of Yangtze River Delta,Zhejiang University,Jiaxing 314102,China
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Chinese bayberry fruit Prodelphinidins Structure α-Glucosidase Postprandial hyperglycemia
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维普
