基于纳剂量学量模型的碳离子束相对生物学效应计算
Calculation of relative biological effectiveness of carbon ion beam based on nano-dosimetric model
欧海峰 1常浩恩 1王梦婷 1杨立旺1
作者信息
- 1. 河南工业大学理学院,河南郑州 450001
- 折叠
摘要
目前癌症严重影响人类的健康,迫切需要一种能有效治疗癌症的手段.碳离子束由于其具有较高的生物学效应和独特的布拉格峰,被认为是极具有潜在价值的放疗射线.主要利用基于纳剂量学量的LNDM(Logistic NanoDosimetry Model)模型计算不同入射能量碳离子束在水模体的相对生物学效应(Relative Biological Effectiveness,RBE).使用GATE模拟工具得到碳离子束及其碎片在水模体中不同深度的能谱和剂量,利用预先计算的带电离子纳剂量学量数据库计算得到碳离子束的四个纳剂量学量M1、M1C2、F2和F3C2,基于LNDM模型计算碳离子束的RBE.结果表明,碳离子束的RBE峰值随着入射能量的增加而逐渐降低,并且RBE峰值出现在布拉格峰下降沿附近.
Abstract
Cancer is now seriously affecting human health and there is an urgent need for a means to effectively treat it.Carbon ion beams are considered to be extremely potentially valuable radiotherapy rays due to their high biological effects and unique Bragg peaks.In this study,the Relative Biological Effectiveness(RBE)of carbon ion beams in aqueous models with different incident energies was calculated using the LNDM(Logistic NanoDosimetry Model)model based on nano-dosimetry quantities.The energy spectra and doses of carbon ion beams and their fragments at different depths in water phantom are obtained using the GATE simulation tool.The four nano-dosimetric quantities M1,M1C2,F2 and F3C2 of carbon ion beams are calculated using the pre-calculated database of charged ion nano-dosimetric quantities,and the RBE of carbon ion beams is calculated based on the LNDM model.The results show that the RBE peak of the carbon ion beam gradually decreases with increasing incident energy,and the RBE peak appears near the falling edge of the Bragg peak.
关键词
碳离子束/相对生物学效应/蒙特卡罗模拟/纳剂量学量Key words
carbon ion beam/relative biological effectiveness/monte Carlo simulation/nanodosimetry quantity引用本文复制引用
基金项目
河南省科技攻关计划(202102310207)
河南工业大学高层次人才科研基金(2018BS059)
出版年
2024
NETL
NSTL
万方数据