Calculation of relative biological effectiveness of carbon ion beam based on nano-dosimetric model
Cancer is now seriously affecting human health and there is an urgent need for a means to effectively treat it.Carbon ion beams are considered to be extremely potentially valuable radiotherapy rays due to their high biological effects and unique Bragg peaks.In this study,the Relative Biological Effectiveness(RBE)of carbon ion beams in aqueous models with different incident energies was calculated using the LNDM(Logistic NanoDosimetry Model)model based on nano-dosimetry quantities.The energy spectra and doses of carbon ion beams and their fragments at different depths in water phantom are obtained using the GATE simulation tool.The four nano-dosimetric quantities M1,M1C2,F2 and F3C2 of carbon ion beams are calculated using the pre-calculated database of charged ion nano-dosimetric quantities,and the RBE of carbon ion beams is calculated based on the LNDM model.The results show that the RBE peak of the carbon ion beam gradually decreases with increasing incident energy,and the RBE peak appears near the falling edge of the Bragg peak.
carbon ion beamrelative biological effectivenessmonte Carlo simulationnanodosimetry quantity
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