Research progress on the construction of chiral cyclopentenone by Nazarov reaction
Nazarov reaction is acid-catalyzed rearrangement of divinyl ketone into cyclopentenone.Chiral cyclopentenone has been attracting the attention of organic synthesis practitioners due to its unique structure and diverse reaction site activity.Considering that there have been few reviews of such reactions recently and in order to allow practitioners to have a more thorough understanding of the progress of this research direction,this article will summarize the reports of Nazzarov reaction to construct chiral cyclopentenone in the past five years,which are divided into three categories:Lewis acid catalysis,Brønsted acid catalysis and other types of conditions.Further research directions will be prospected,which is of great significance for development and research of Nazarov reaction.
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