首页|Expert consensus on the diagnosis,treatment,and prevention of respiratory syncytial virus infections in children

Expert consensus on the diagnosis,treatment,and prevention of respiratory syncytial virus infections in children

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Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare burden.There is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in children.Data sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Library,using variations in terms for"respiratory syncytial virus","RSV","lower respira-tory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of consensus.Although supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled out.Conclusions This consensus,based on international and national scientific evidence,reinforces the current recommenda-tions and integrates the recent advances for optimal care and prevention of RSV infections.Further improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

Consensus preventionRespiratory syncytial virusTreatment

Xian-Li Zhang、Xi Zhang、Wang Hua、Zheng-De Xie、Han-Min Liu、Hai-Lin Zhang、Bi-Quan Chen、Yuan Chen、Xin Sun、Yi Xu、Sai-Nan Shu、Shun-Ying Zhao、Yun-Xiao Shang、Ling Cao、Yan-Hui Jia、Luo-Na Lin、Jiong Li、Chuang-Li Hao、Xiao-Yan Dong、Dao-Jiong Lin、Hong-Mei Xu、De-Yu Zhao、Mei Zeng、Zhi-Min Chen、Li-Su Huang

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Department of Infectious Disease,Children's Hospital,Zhejiang University School of Medicine,3333 Binsheng Road,Binjiang District,Hangzhou 310052,China

Clinical Research Unit,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China

Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,Beijing,China

Department of Pediatric Pulmonology,West China Second University Hospital,Sichuan University,Chengdu,China

Department of Pediatric Pulmonology,the Second Affiliated Hospital & Yuying Children's Hospital,Wenzhou Medical University,Wenzhou,China

Department of Infectious Disease,Anhui Provincial Children's Hospital,Hefei,China

Department of Pediatrics,the Second Hospital of Hebei Medical University,Shijiazhuang,China

Department of Pediatrics,Xijing Hospital,the Fourth Military Medical University,Xi'an,China

Department of Infectious Disease,Guangzhou Women and Children's Medicine Center,Guangzhou Medicine University,Guangzhou,China

Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

Department of Respiratory Disease,Beijing Children's Hospital,Capital Medical University,Beijing,China

Department of Pediatric Respiratory,Shengjing Hospital of China Medical University,Shenyang,China

Respiratory Department,Children's Hospital Affiliated to Capital Institute of Pediatrics,Beijing,China

Department of Clinical Epidemiology,Aarhus University,Aarhus,Denmark

Department of Respirology,Children's Hospital of Soochow University,Suzhou,China

Department of Respiratory,Children's Hospital of Shanghai,Children's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China

Department of Infectious Disease,Hainan Women and Children's Medical Center,Haikou,China

Department of Infectious Disease,Children's Hospital of Chongqing Medical University,Chongqing,China

Department of Respiratory,Children's Hospital of Nanjing Medical University,Nanjing,China

Department of Infectious Diseases,Children's Hospital of Fudan University,399 Wanyuan Road,Minhang District,Shanghai 201102,China

Department of Respiratory Diseases,Children's Hospital,Zhejiang University School of Medicine,3333 Binsheng Road,Binjiang District,Hangzhou 310052,China

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2024

世界儿科杂志(英文版)

世界儿科杂志(英文版)

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ISSN:
年,卷(期):2024.20(1)
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