首页|Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery:new evidence from human populations and mice

Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery:new evidence from human populations and mice

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Background Tetralogy of Fallot(TOF)is the most common cyanotic congenital heart disease.Children with TOF would be confronted with neurological impairment across their lifetime.Our study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with TOF.Methods We used mass spectrometry(MS)technology to assess the levels of serum metabolites,Wechsler preschool and primary scale of intelligence-Fourth edition(WPPSI-Ⅳ)index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging(MRI)to detect cortical morphological changes.Results Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal index.Meanwhile,preoperative SpO2 was negatively correlated with levels of serum cortisone after adjusting for all covariates.Furthermore,after intervening levels of cortisone in chronic hypoxic model mice,total brain volumes were reduced at both postnatal(P)11.5 and P30 days.Conclusions Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmen-tal impairment in children with TOF.Our study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.

CognitionCortisoneMRINeurodevelopmentTetralogy of Fallot

Si-Yu Ma、Yu-Ting Liu、Yue-Shuang Cun、Qiang Wang、Ming-Cui Fu、Ke-De Wu、Xin-Yu Cai、Shu-Ting Cheng、Nishant Patel、Min Da、Liang Hu、Zhuoga Deqin、Xue-Jun Kang、Ming Yang、Xu-Ming Mo

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Department of Cardiothoracic Surgery,Children's Hospital of Nanjing Medical University,72 Guangzhou Road,Nanjing 210008,China

Department of Radiology,Children's Hospital of Nanjing Medical University,72 Guangzhou Road,Nanjing 210008,China

Medical School of Nanjing University,Nanjing 210093,China

Key Laboratory of Child Development and Learning Science,Research Center For Learning Science,School of Biological Sciences & Medical Engineering,Ministry of Education,Southeast University,Nanjing 210096,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of China

8227031081970265

2024

10.1007/s12519-023-00754-2

世界儿科杂志(英文版)

世界儿科杂志(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.20(2)
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