首页|Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta-analysis,and meta-regression

Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta-analysis,and meta-regression

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Background Retinopathy of prematurity(ROP)is generally considered to be more frequent in males than in females.However,it is not known whether sex differences in ROP affect all degrees of the condition,are global and have changed as neonatology has developed.We aimed to conduct a systematic review and meta-analysis of studies addressing sex differ-ences in the risk of developing ROP.Methods PubMed/MEDLINE and Embase databases were searched.The frequentist,random-effects risk ratio(RR)and 95％confidence interval(CI)were calculated.Bayesian model averaged(BMA)meta-analysis was used to calculate the Bayes factors(BFs).The BF10 is the ratio of the probability of the data under the alternative hypothesis(H1)over the probability of the data under the null hypothesis(H0).Results We included 205 studies(867,252 infants).Frequentist meta-analysis showed a positive association between male sex and severe ROP(113 studies,RR=1.14,95％CI=1.07-1.22)but no association with any ROP(144 studies,RR=1.00,95％CI=0.96-1.03).BMA showed extreme evidence in favor of H1 for severe ROP(BF10=71,174)and strong evidence in favor of H0 for any ROP(BF10=0.05).The association between male sex and severe ROP remained stable over time and was present only in cohorts from countries with a high or high-middle sociodemographic index.Conclusions Our study confirms the presence of a male disadvantage in severe ROP but not in less severe forms of the dis-ease.There are variations in the sex differences in ROP,depending on geographical location and sociodemographic level of the countries.

Oxidative stressRetinopathy of prematuritySex characteristics

Tamara M.Hundscheid、Silvia Gulden、Mohamad F.Almutairi、Franti?ek Barto?、Giacomo Cavallaro、Eduardo Villamor

展开 >

Division of Neonatology,Department of Pediatrics,MosaKids Children's Hospital,Maastricht University Medical Center(MUMC+),School for Oncology and Reproduction(GROW),Maastricht University,P.Debyelaan 25.P.O.Box 5800,6202 AZ Maastricht,The Netherlands

Neonatal Intensive Care Unit,Sant'Anna Hospital,Como,Italy

Department of Psychology,University of Amsterdam,1001 NK Amsterdam,The Netherlands

Neonatal Intensive Care Unit,Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico,Milan,Italy

展开 >

2024

10.1007/s12519-023-00775-x

世界儿科杂志(英文版)

世界儿科杂志(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.20(4)
  • 50