首页|Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

Prenatal and postnatal factors associated with sudden infant death syndrome:an umbrella review of meta-analyses

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Background Comprehensive quantitative evidence on the risk and protective factors for sudden infant death syndrome(SIDS)effects is lacking.We investigated the risk and protective factors related to SIDS.Methods We conducted an umbrella review of meta-analyses of observational and interventional studies assessing SIDS-related factors.PubMed/MEDLINE,Embase,EBSCO,and Google Scholar were searched from inception until January 18,2023.Data extraction,quality assessment,and certainty of evidence were assessed by using A Measurement Tool Assess-ment Systematic Reviews 2 following PRISMA guidelines.According to observational evidence,credibility was graded and classified by class and quality of evidence(CE;convincing,highly suggestive,suggestive,weak,or not significant).Our study protocol was registered with PROSPERO(CRD42023458696).The risk and protective factors related to SIDS are presented as equivalent odds ratios(eORs).Results We identified eight original meta-analyses,including 152 original articles,covering 12 unique risk and protec-tive factors for SIDS across 21 countries/regions and five continents.Several risk factors,including prenatal drug expo-sure[eOR=7.84(95％CI=4.81-12.79),CE=highly suggestive],prenatal opioid exposure[9.55(95％CI=4.87-18.72),CE=suggestive],prenatal methadone exposure[9.52(95％CI=3.34-27.10),CE=weak],prenatal cocaine exposure[4.38(95％CI=1.95-9.86),CE=weak],prenatal maternal smoking[2.25(95％CI=1.95-2.60),CE=highly suggestive],postnatal maternal smoking[1.97(95％CI=1.75-2.22),CE=weak],bed sharing[2.89(95％CI=1.81-4.60),CE=weak],and infants found with heads covered by bedclothes after last sleep[11.01(95％CI=5.40-22.45),CE=suggestive],were identified.On the other hand,three protective factors,namely,breastfeeding[0.57(95％CI=0.39-0.83),CE=non-significant],supine sleeping position[0.48(95％CI=0.37-0.63),CE=suggestive],and pacifier use[0.44(95％CI=0.30-0.65),CE=weak],were also identified.Conclusions Based on the evidence,we propose several risk and protective factors for SIDS.This study suggests the need for further studies on SIDS-related factors supported by weak credibility,no association,or a lack of adequate research.

InfantProtective factorRisk factorSudden infant death syndromeUmbrella review

Tae Hyeon Kim、Hyeri Lee、Selin Woo、Hayeon Lee、Jaeyu Park、Guillaume Fond、Laurent Boyer、Jong Woo Hahn、Jiseung Kang、Dong Keon Yon

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Department of Medicine,Kyung Hee University College of Medicine,Seoul,South Korea

Center for Digital Health,Medical Science Research Institute,Kyung Hee University College of Medicine,Seoul,South Korea

Department of Regulatory Science,Kyung Hee University,Seoul,South Korea

Department of Biomedical Engineering,Kyung Hee University,Yongin,South Korea

CEReSS-Health Service Research and Quality of Life Center,Assistance Publique des Hôpitaux de Marseille,Aix-Marseille University,Marseille,France

Department of Pediatrics,Seoul National University College of Medicine,Seoul,South Korea

Department of Pediatrics,Seoul National University Bundang Hospital,Seongnam,South Korea

Department of Anesthesia,Critical Care and Pain Medicine,Massachusetts General Hospital,149 13th Street,Room 4140,Charlestown,Boston,MA,USA

Division of Sleep Medicine,Harvard Medical School,Boston,MA,USA

Department of Pediatrics,Kyung Hee University Medical Center,Kyung Hee University College of Medicine,23 Kyungheedae-ro,Dongdaemun-gu,Seoul 02447,South Korea

Department of Precision Medicine,Kyung Hee University College of Medicine,Seoul

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National Research Foundation of Korea(NRF)grant funded by the Korea government

MSITRS-2023-00248157

2024

10.1007/s12519-024-00806-1

世界儿科杂志(英文版)

世界儿科杂志(英文版)

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年,卷(期)：2024.20(5)
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