Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection:a randomized controlled trial

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外文摘要：Background Saline nasal irrigation is an effective therapy for relieving common cold symptoms.This study aimed to inves-tigate and explore the efficacy of physiological seawater nasal irrigation(PSNI)on children with mild and asymptomatic infection with Omicron.Methods This randomized controlled trial was conducted in Shanghai,China,and 403 children with mild and asymptomatic infection with Omicron were included.These children were allocated into the PSNI group and the control group.The pri-mary outcome was the duration of viral shedding(DVS),and the secondary outcome was the change in clinical symptoms.Results The median age of all participants was 5.59(6.26)years old.The DVS was significantly shorter in the PSNI group[2.40(1.13)]than in the control group[3.09(2.14)](P=0.014).The multivariable Cox regression model also showed that patients in the PSNI group had an increased probability of shorter DVS compared with patients in the control group[hazard ratio(HR),1.27;95％confidence interval(CI),1.04-1.55;P=0.017].Subgroup analysis suggested that the DVS of patients without full vaccination was significantly reduced in the PSNI group.The proportions of runny nose and stuffy nose were apparently reduced in the first three days in the PSNI group or the control group,but there was no evidence showing that PSNI contributes to the benefit compared with the control group.Conclusion PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant.

外文关键词：

ChildrenDuration of viral sheddingOmicronPhysiological seawater nasal irrigation

作者：

Ji-Lei Lin、Fen Zhang、Yan-Bo Li、Shu-Hua Yuan、Jin-Hong Wu、Jing Zhang、Lei Zhang、Yi He、Jie Chen、Yong Yin

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作者单位：

Department of Respiratory Medicine,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China

University of British Columbia,Vancouver,Canada

Information Technology Department,Shanghai Children's Medical Center National Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China

Department of Otorhinolaryngology,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China

Department of Respiratory Medicine,Sanya Women and Children's Hospital Affiliated to Hainan Medical College,Hainan Branch of Shanghai Children's Medical Center,Sanya,China

Department of Respiratory Medicine,Linyi Maternal and Child Healthcare Hospital,Linyi,China

Shanghai Children's Medical Center Pediatric Medical Complex(Pudong),Shanghai,C

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基金：

Health and Family Planning Research Project of Pudong New Area Health Committee

项目编号：

PW2021E-06

出版年：

2024

DOI：

10.1007/s12519-023-00749-z

世界儿科杂志(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.20(5)

参考文献量25