Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection:a randomized controlled trial

Ji-Lei Lin ¹Fen Zhang ¹Yan-Bo Li ²Shu-Hua Yuan ¹Jin-Hong Wu ¹Jing Zhang ¹Lei Zhang ¹Yi He ³Jie Chen ⁴Yong Yin⁵

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作者信息

1. Department of Respiratory Medicine,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China
2. University of British Columbia,Vancouver,Canada
3. Information Technology Department,Shanghai Children's Medical Center National Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China
4. Department of Otorhinolaryngology,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China
5. Department of Respiratory Medicine,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dongfang Road,Pudong District,Shanghai,China;Department of Respiratory Medicine,Sanya Women and Children's Hospital Affiliated to Hainan Medical College,Hainan Branch of Shanghai Children's Medical Center,Sanya,China;Department of Respiratory Medicine,Linyi Maternal and Child Healthcare Hospital,Linyi,China;Shanghai Children's Medical Center Pediatric Medical Complex(Pudong),Shanghai,C
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Abstract

Background Saline nasal irrigation is an effective therapy for relieving common cold symptoms.This study aimed to inves-tigate and explore the efficacy of physiological seawater nasal irrigation(PSNI)on children with mild and asymptomatic infection with Omicron.Methods This randomized controlled trial was conducted in Shanghai,China,and 403 children with mild and asymptomatic infection with Omicron were included.These children were allocated into the PSNI group and the control group.The pri-mary outcome was the duration of viral shedding(DVS),and the secondary outcome was the change in clinical symptoms.Results The median age of all participants was 5.59(6.26)years old.The DVS was significantly shorter in the PSNI group[2.40(1.13)]than in the control group[3.09(2.14)](P=0.014).The multivariable Cox regression model also showed that patients in the PSNI group had an increased probability of shorter DVS compared with patients in the control group[hazard ratio(HR),1.27;95％confidence interval(CI),1.04-1.55;P=0.017].Subgroup analysis suggested that the DVS of patients without full vaccination was significantly reduced in the PSNI group.The proportions of runny nose and stuffy nose were apparently reduced in the first three days in the PSNI group or the control group,but there was no evidence showing that PSNI contributes to the benefit compared with the control group.Conclusion PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant.

Key words

Children/Duration of viral shedding/Omicron/Physiological seawater nasal irrigation

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基金项目

Health and Family Planning Research Project of Pudong New Area Health Committee(PW2021E-06)

出版年

2024

世界儿科杂志(英文版)

CSTPCD

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参考文献量25

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