首页|Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China
Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China
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Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up time.This study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gesta-tional weight gain(GWG)with childhood weight trajectories in a 7-year birth cohort.Methods A total of 946 mother-child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 years.The outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory groups.Results Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2％),constant normal weight(42.8％),and high or increasing trajectory[at risk of overweight(16.9％),progressive overweight(11.0％)and progressive obesity(4.1％)].Maternal prepregnancy overweight was associated with 1.72(95％CI 1.14-2.60,P=0.01)to 4.02(95％CI 1.94-8.36,P＜0.001)times the risk of all high or increasing trajectory groups,and excessive GWG was related to groups at risk of overweight[relative risk ratio(RRR)2.09,95％CI 1.27-3.46,P=0.004]and progressive obe-sity(RRR 3.33,95％CI 1.13-9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95％CI 2.53-4.95,P＜0.001)to 6.18(95％CI 4.05-9.42,P＜0.001)].Conclusion Maternal prepregnancy overweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.
Institute of Child and Adolescent Health,School of Public Health,Peking University Health Science Center,No.38 Xueyuan Rd,Haidian District,Beijing 100191,China
Tianjin Women and Children's Health Center,No.96 Guizhou Rd,Heping District,Tianjin 300070,China
Menzies Health Institute Queensland,Griffith University,Nathan,QLD 4111,Australia
国家自然科学基金Chinese Association for Student Nutrition & Health Promotion
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