Abstract
Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up time.This study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gesta-tional weight gain(GWG)with childhood weight trajectories in a 7-year birth cohort.Methods A total of 946 mother-child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 years.The outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory groups.Results Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2％),constant normal weight(42.8％),and high or increasing trajectory[at risk of overweight(16.9％),progressive overweight(11.0％)and progressive obesity(4.1％)].Maternal prepregnancy overweight was associated with 1.72(95％CI 1.14-2.60,P=0.01)to 4.02(95％CI 1.94-8.36,P＜0.001)times the risk of all high or increasing trajectory groups,and excessive GWG was related to groups at risk of overweight[relative risk ratio(RRR)2.09,95％CI 1.27-3.46,P=0.004]and progressive obe-sity(RRR 3.33,95％CI 1.13-9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95％CI 2.53-4.95,P＜0.001)to 6.18(95％CI 4.05-9.42,P＜0.001)].Conclusion Maternal prepregnancy overweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.
基金项目
国家自然科学基金(81903344)
Chinese Association for Student Nutrition & Health Promotion(CASNHP-MJN2023-11)
NETL
NSTL
万方数据