首页|A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in 2016.Methods A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was con-ducted.Patient demographics,treatment protocols,and other related information were collected.Cox regression models and Kaplan-Meier curve methods were used.Results The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,respectively.The 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,respec-tively.The 4-year OS was 100%,97.3%,94.4%,and 86.8%,respectively.Cox regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 relapsed.Patients with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those ≤ 75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 therapy.Age ≥ 8 years,R+,and E+were independent risk factors for prognosis.Patients with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

Alpha-fetoproteinHepatoblastomaMulticenterProspective studySurvival

Meng-Jie Tang、Xiao-Li Ma、Xiang-Ling He、Wei-Hua Pan、Xiao-Hong Zhang、Sha-Yi Jiang、Ju Gao、Fu Li、Wei Yao、Song Gu、Wei-Ling Zhang、Qiang Zhao、Shi-Hao Huang、Yong-Jun Fang、Wei Liu、Hui-Zhong Niu、Chun-Mei Wang、Li-Rong Sun、Hui Gao、Yun-Peng Dai、Shun-Gen Huang、Zhi-Yong Zhong、Xi-Ge Wang、Zhong-Rong Li、Liang-Chun Yang、Ye-Ming Wu、Huan-Min Wang、Xin Sun、Xiao-Jun Yuan

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Department of Pediatric Hematology/Oncology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,No.1665,Kongjiang Road,Yangpu District,Shanghai 200092,China

Medical Oncology Department,Pediatric Oncology Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China

Department of Hematology/Oncology,Children's Medical Center,Hunan Provincial People's Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 41005,China

Department of Pediatric Surgery,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

Department of Hematology/Oncology,Guangzhou Women and Children's Medical Center,National Children's Medical Center for South Central Region,Guangzhou 510623,China

Department of Hematology,Shanghai Children's Hospital,Shanghai Jiao Tong University,Shanghai 200062,China

Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu 610041,China

Department of Hematology/Oncology,Qilu Children's Hospital of Shandong University,Jinan 250022,China

Department of Pediatric Surgery,Children's Hospital of Fudan University,Shanghai 201102,China

Department of General Surgery,Shanghai Children's Medical Center(National Children's Medical Center-Shanghai),Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China

Department of Pediatrics,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China

Department of Pediatric Oncology,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China

Department of Hematology/Oncology,Children's Hospital of Nanjing Medical University,Nanjing 210008,China

Department of Hematology/Oncology,Henan Children's Hospital,Zhengzhou 450018,China

Department of Pediatric General Surgery,Hebei Children's Hospital of Hebei Medical University,Shijiazhuang City 050031,China

Children's Hospital,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

Department of Paediatric Hematology/Oncology,the Affiliated Hospital of Qingdao University,Qingdao 266000,China

Department of Paediatric Hematology/Oncology,Dalian Women and Children's Medical Group,Dalian 116037,China

Department of Pediatric Hematology/Oncology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China

Department of General Surgery,Children's Hospital of Soochow University,Suzhou 215028,China

Department of Pediatric Surgery,the Second Hospital of HeBei Medical University,Shijiazhuang 050000,China

Department of Paediatric Hematology/Oncology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

Department of Pediatric Surgery,the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325027,China

Department of Pediatrics,Xiangya Hospital Central South University,Changsha 410008,China

Department of Surgical Oncology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China

Clinical Research and Innovation Unit,XinHua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

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Shanghai Municipal Hospital New Frontier Technology Joint Key Project,Shanghai,China

SHDC12019115

2024

世界儿科杂志(英文版)

世界儿科杂志(英文版)

CSTPCD
ISSN:
年,卷(期):2024.20(6)
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