首页|Clinical-based phenotypes in children with pediatric post-COVID-19 condition

Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of children.This study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this condition.Methods Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March 2023.Demographic factors and information on post-COVID symptoms,comorbidities,and impact on daily life were collected.Clinical clusters were identified using an unsupervised and unbiased approach for mixed data types.Results Analysis of 111 patients(aged 3-18 years)revealed three distinct clusters within PPCC.Cluster 1(n=62,median age=15 years)predominantly consisted of girls(74.2％).These patients suffered relatively more from exercise intolerance,dyspnea,and smell disorders.Cluster 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5％girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and arthralgia.Cluster 3(n=16,median age=11 years)had a higher proportion of boys(75.0％),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experi-enced a lower impact on daily life.Conclusions This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily life.These findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

AdolescentsClustersLong COVIDPediatricPhenotypesPost-COVID syndrome

Lieke C.E.Noij、Jelle M.Blankestijn、Coen R.Lap、Marlies A.van Houten、Giske Biesbroek、Anke-Hilse Maitland-van der Zee、Mahmoud I.Abdel-Aziz、Johannes B.van Goudoever、Mattijs W.Alsem、Caroline L.H.Brackel、Kim J.Oostrom、Simone Hashimoto、Suzanne W.J.Terheggen-Lagro

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Department of Pediatric Pulmonology and Allergy,Amsterdam UMC,Location AMC,Emma Children's Hospital,Amsterdam University Medical Center,Room G2-222,Meibergdreef 9,1105AZ Amsterdam,The Netherlands

Department of Pulmonary Medicine,Amsterdam UMC,Amsterdam,The Netherlands

Department of Pediatrics,Spaarne Gasthuis,Hoofddorp,The Netherlands

Department of Pediatrics,Emma Children's Hospital,Amsterdam University Medical Center,Amsterdam,The Netherlands

Department of Rehabilitation Medicine,Amsterdam Movement Sciences,Meibergdreef 9,Amsterdam,The Netherlands

Department of Paediatric Pulmonology,Department of Paediatrics,Tergooi MC,Hilversum,The Netherlands

Department of Child and Adolescent Psychiatry and Psychosocial Care,Amsterdam UMC,Amsterdam Reproduction and Development,Amsterdam,The Netherlands

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2024

10.1007/s12519-024-00805-2

世界儿科杂志(英文版)

世界儿科杂志(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.20(7)